Article
Association of the presence of residual anti-Toxoplasma gondii IgM in pregnant women and their respective family groups in Miracema, Northwest Rio de Janeiro, Brazil
Registro en:
RIBEIRO, Ana Claudia; MUTIS, Martha Suarez; FERNANDES, Octavio. Association of the presence of residual anti-Toxoplasma gondii IgM in pregnant women and their respective family groups in Miracema, Northwest Rio de Janeiro, Brazil. Mem Inst Oswaldo Cruz, v.103, n.6, p.591-594, Sept. 2008.
0074-0276
1678-8060
Autor
Ribeiro, Ana Claudia
Mutis, Martha Suarez
Fernandes, Octavio
Resumen
The seroprevalence of toxoplasmosis in 832 pregnant women in Miracema, Rio de Janeiro, was determined and
75.1% (625) and 2.0% (17) were anti-Toxoplasma gondii IgG and IgM positive, respectively. Out of the 17 IgM positive
pregnant women, only one had low avidity IgG corresponding to the acute phase of the infection. All the other
women presented with high avidity IgG and also presented with residual IgM anti-T. gondii. Of this sample, 106
received home visits (this includes 11 family nuclei of pregnant women with residual IgM anti-T. gondii, 68 nuclei of
only IgG positive pregnant women and 27 nuclei of pregnant women with no antibodies to anti-T. gondii), resulting
in 267 individuals visited. Out of these 267 individuals, 21 were positive for IgG and IgM anti-T. gondii and were
candidates for the IgG avidity test. All of them presented with high avidity IgG and residual IgM. Five of these IgM+
individuals were (5/238; 2.1%) relatives of IgM negative pregnant women. The other 16 (16/29; 55.2%) were relatives
of IgM+ pregnant women who were positive for residual IgM anti-T. gondii. This association was statistically significant
(p = 0.0000). The analysis presented herein raises questions regarding the presence of residual IgM anti-T.
gondii such as genetic determinants or even constant antigenic stimuli for the same family cluster.