Najim Lahrouchi Amsterdam UMC. University of Amsterdam. Heart Center. Department of Clinical and Experimental Cardiology. Amsterdam Cardiovascular Sciences. Amsterdam, The Netherlands/ Program in Medical and Population Genetics. Broad Institute of Harvard and MIT.Cambridge, MA, USA/Cardiovascular Research Center. Center for Genomic Medicine. Massachusetts General Hospital. Boston, MA, USA. Aaron Isaacs Deptartment of Physiology. Cardiovascular Research Institute Maastricht CARIM. Maastricht University. Maastricht, The Netherlands/Maastricht Center for Systems Biology MaCSBio. Maastricht University. Maastricht, The Netherlands. ThuyVy Duong McKusick‐Nathans Institute. Department of Genetic Medicine. Johns Hopkins University. School of Medicine. Baltimore, MD, USA. Luisa Foco Eurac Research. Institute for Biomedicine affiliated with the University of Lübeck. Bolzano, Italy. Farah Ahmed William Harvey Research Institute. Clinical Pharmacology. Queen Mary University of London. London, UK. Jennifer A. Brody Cardiovascular Health Research Unit. Department of Medicine. University of Washington. Seattle, WA, USA. Reem Salman William Harvey Research Institute. Clinical Pharmacology. Queen Mary University of London. London, UK. Raymond Noordam Department of Internal Medicine. section of Gerontology and Geriatrics. Leiden University Medical Center. Leiden, The Netherlands. Jan-Walter Benjamins University of Groningen. University Medical Center Groningen. Department of Cardiology. Groningen, The Netherlands. Jeffrey Haessler Public Health Sciences Division. Fred Hutchinson Cancer Center. Seattle, WA, USA. Leo-Pekka Lyytikäinen Department of Clinical Chemistry. Fimlab Laboratories. Tampere, Finland/Department of Clinical Chemistry. Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology. Tampere University. Tampere, Finland. Linda Repetto Centre for Global Health Research. Usher Institute. University of Edinburgh. Edinburgh, Scotland. Maria Pina Concas Institute for Maternal and Child Health – IRCCS “Burlo Garofolo”. Trieste, Italy. Marten E. van den Berg Department of Epidemiology. Erasmus MC – University Medical Center. Rotterdam, The Netherlands. Stefan Weiss DZHK German Centre for Cardiovascular Research; partner site Greifswald, Greifswald, Germany/Interfaculty Institute for Genetics and Functional Genomics. Department of Functional Genomics. University Medicine Greifswald. Greifswald, Germany. Antoine R. Baldassari Department of Epidemiology. Gillings School of Global Public Health. University of North Carolina at Chapel Hill. Chapel Hill, USA. Traci M. Bartz Cardiovascular Health Research Unit. Departments of Biostatistics and Medicine. University of Washington. Seattle, WA, USA. James P. Cook Department of Health Data Science. University of Liverpool. Liverpool, UK. Daniel S. Evans California Pacific Medical Center. Research Institute. San Francisco, CA, USA. Rebecca Freudling Department of Cardiology. University Hospital. LMU Munich, Munich, Germany/Institute of Genetic Epidemiology. Helmholtz Zentrum München - German Research Center for Environmental Health. Neuherberg, Germany. Oliver Hines Genetics Research Centre. St George’s University of London. London, UK/Department of Medical Statistics. London School of Hygiene and Tropical Medicine. London, UK. Jonas L. Isaksen Laboratory of Experimental Cardiology. Department of Biomedical Sciences. University of Copenhagen. Copenhagen, Denmark. Honghuang Lin National Heart Lung and Blood Institute’s and Boston University’s Framingham Heart Study, Framingham, MA, USA/Section of Computational Biomedicine. Department of Medicine. Boston University School of Medicine. Boston, MA, USA. Hao Mei Department of Data Science University of Mississippi Medical Center Jackson, USA. Arden Moscati The Charles Bronfman Institute for Personalized Medicine. Icahn School of Medicine at Mount Sinai. New York, NY, USA. Martina Müller-Nurasyid Institute of Genetic Epidemiology. Helmholtz Zentrum München - German Research Center for Environmental Health. Neuherberg, Germany/ IBE. Faculty of Medicine. LMU Munich, Munich, Germany/Institute of Medical Biostatistics. Epidemiology and Informatics IMBEI. University Medical Center. Johannes Gutenberg University. Mainz, Germany. Casia Nursyifa Novo Nordisk Foundation Center for Basic Metabolic Research. Faculty of Health and Medical Sciences. University of Copenhagen. Copenhagen, Denmark. Yong Qian Translational Gerontology Branch. National Institute on Aging National Institute of Health. Baltimore, US. Anne Richmond MRC Human Genetics Unit. Institute of Genetics and Cancer. University of Edinburgh. Western General Hospital. Edinburgh, UK. Carolina Roselli University of Groningen. University Medical Center Groningen. Department of Cardiology. Groningen, The Netherlands/ Cardiovascular Disease Initiative. Broad Institute. Cambridge, MA, USA. Kathleen A. Ryan Division of Endocrinology, Diabetes, and Nutrition. University of Maryland School of Medicine. Baltimore, MD, USA/Program for Personalized and Genomic Medicine. University of Maryland School of Medicine. Baltimore, MD, USA. Eduardo Tarazona-Santos Department of Genetics, Ecology and Evolution. Instituto de Ciências Biológicas. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil. Sébastien Thériault Population Health Research Institute. McMaster University. Hamilton, Canada/Department of Molecular Biology. Medical Biochemistry and Pathology. Université Laval, Quebec, Canada. Stefan van Duijvenboden William Harvey Research Institute. Clinical Pharmacology. Queen Mary University of London. London, UK/Institute of Cardiovascular Sciences. University of College London. London, UK. Helen R. Warren William Harvey Research Institute. Clinical Pharmacology. Queen Mary University of London. London, UK/NIHR Barts Cardiovascular Biomedical Research Centre. Barts and The London School of Medicine and Dentistry. Queen Mary University of London. London, UK. Jie Yao Institute for Translational Genomics and Population Sciences/The Lundquist Institute at Harbor-UCLA Medical Center. Torrance, CA, USA. Dania Raza William Harvey Research Institute. Clinical Pharmacology. Queen Mary University of London. London, UK/Brighton and Sussex Medical School. Brighton, UK. Stefanie Aeschbacher Cardiovascular Research Institute Basel. University Hospital Basel. University of Basel. Basel, Switzerland. Gustav Ahlberg Laboratory for Molecular Cardiology. The Heart Centre. Department of Cardiology. Copenhagen University Hospital. Rigshospitalet, Copenhagen, Denmark/Department of Biomedical Sciences. University of Copenhagen. Copenhagen, Denmark. Alvaro Alonso Department of Epidemiology. Rollins School of Public Health. Emory University. Atlanta, GA, USA. Laura Andreasen Laboratory for Molecular Cardiology. The Heart Centre. Department of Cardiology. Copenhagen University Hospital. Rigshospitalet, Copenhagen, Denmark/Department of Biomedical Sciences. University of Copenhagen. Copenhagen, Denmark. Joshua C. Bis Cardiovascular Health Research Unit. Department of Medicine. University of Washington. Seattle, WA, USA. Eric Boerwinkle Human Genetics Center. Department of Epidemiology. Human Genetics, and Environmental Sciences. School of Public Health. The University of Texas Health Science Center at Houston. Houston, TX, USA/Human Genome Sequencing Center. Baylor College of Medicine. Houston, TX, USA. Archie Campbell Usher Institute. University of Edinburgh Nine, Edinburgh Bioquarter. Edinburgh, UK/Health Data Research UK. University of Edinburgh Nine, Edinburgh Bioquarter. Edinburgh, UK/Centre for Genomic and Experimental Medicine. Institute of Genetics and Cancer. University of Edinburgh. Western General Hospital. Edinburgh, UK. Eulalia Catamo Institute for Maternal and Child Health – IRCCS “Burlo Garofolo”. Trieste, Italy. 18 Department of Epidemiology. Erasmus MC – University Medical Center. Rotterdam, The Netherlands. Massimiliano Cocca Institute for Maternal and Child Health – IRCCS “Burlo Garofolo”. Trieste, Italy. 18 Department of Epidemiology. Erasmus MC – University Medical Center. Rotterdam, The Netherlands. Michael J. Cutler Intermountain Heart Institute. Intermountain Medical Center. Murray, UT, USA. Dawood Darbar Department of Medicine. University of Illinois at Chicago. Chicago, USA. Alessandro De Grandi Eurac Research. Institute for Biomedicine affiliated with the University of Lübeck. Bolzano, Italy. Antonio De Luca Cardiothoracovascular Department. University of Trieste. Trieste, Italy. Jun Ding Translational Gerontology Branch. National Institute on Aging National Institute of Health. Baltimore, US. Christina Ellervik Department of Data and Data Support. Sorø, Denmark/ Department of Clinical Medicine. Faculty of Health and Medical Sciences. University of Copenhagen, Denmark/Department of Laboratory Medicine. Boston Children’s Hospital. Harvard Medical School. Boston, MA, USA. Patrick T. Ellinor Cardiovascular Disease Initiative. Broad Institute. Cambridge, MA, USA/Demoulas Center for Cardiac Arrhythmias and Cardiovascular Research Center. Massachusetts General Hospital, Boston, MA, USA. Stephan B. Felix DZHK German Centre for Cardiovascular Research; partner site Greifswald, Greifswald, Germany/Department of Internal Medicine B - Cardiology, Pneumology, Infectious Diseases. Intensive Care Medicine. Greifswald, Germany/University Medicine Greifswald. Greifswald, Germany. Philippe Froguel 66,67,68, Christian Fuchsberger9,69,70, Martin Gögele 9 Department of Epidemiology and Biostatistics. MRC-PHE Centre for Environment and Health. School of Public Health. Imperial College London. London, UK/University of Lille Nord de France. Lille, France/Institut Pasteur de Lille. Lille, France/Institut Pasteur de Lille. Lille, France. Claus Graff Department of Health Science and Technology. Aalborg University. Aalborg, Denmark. Mariaelisa Graff Department of Epidemiology. University of North Carolina at Chapel Hill. Chapel Hill, NC, USA. Xiuqing Guo Institute for Translational Genomics and Population Sciences/The Lundquist Institute at Harbor-UCLA Medical Center. Torrance, CA, USA/Department of Pediatrics/Harbor-UCLA Medical Center. Torrance, CA, USA/Department of Pediatrics/David Geffen School of Medicine at UCLA. Los Angeles, CA, USA. Torben Hansen Novo Nordisk Foundation Center for Basic Metabolic Research. Faculty of Health and Medical Sciences. University of Copenhagen. Copenhagen, Denmark. Susan R. Heckbert Cardiovascular Health Research Unit. Department of Medicine. University of Washington. Seattle, WA, USA/Department of Epidemiology/University of Washington. Seattle, WA, USA. Paul L. Huang Cardiology Division and Cardiovascular Research Center. Massachusetts General Hospital. Boston, MA, USA. Heikki V. Huikuri Research Unit of Internal Medicine. Medical Research Center Oulu. University of Oulu and University Hospital of Oulu. Oulu, Finland. Nina Hutri-Kähönen Department of Pediatrics. Tampere University Hospital. Tampere, Finland/Department of Pediatrics. Faculty of Medicine and Health Technology. Tampere University. Tampere, Finland/Tampere Centre for Skills Training and Simulation. Faculty of Medicine and Health Technology. Tampere University. Tampere, Finland. M. Arfan Ikram Department of Epidemiology. Erasmus MC – University Medical Center. Rotterdam, The Netherlands. Rebecca D. Jackson Center for Clinical and Translational Science. Ohio State Medical Center. Columbus, OH, USA. Juhani Junttila Research Unit of Internal Medicine. Medical Research Center Oulu. University of Oulu and University Hospital of Oulu. Oulu, Finland. Maryam Kavousi Department of Epidemiology. Erasmus MC – University Medical Center. Rotterdam, The Netherlands. Jan A. Kors Department of Medical Informatics. Erasmus University Medical Center. Rotterdam, NL, The Netherlands. Thiago P. Leal Department of Genetics, Ecology and Evolution. Instituto de Ciências Biológicas. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil/Lerner Research Institute. Cleveland Clinic. Cleveland, OH, USA. Rozenn N. Lemaitre Cardiovascular Health Research Unit. Department of Medicine. University of Washington. Seattle, WA, USA. Henry J. Lin Institute for Translational Genomics and Population Sciences/The Lundquist Institute at Harbor-UCLA Medical Center. Torrance, CA, USA/Department of Pediatrics/Harbor-UCLA Medical Center. Torrance, CA, USA/ Department of Pediatrics/David Geffen School of Medicine at UCLA. Los Angeles, CA, USA. Lars Lind Deptartment of Medical Sciences. Uppsala University. Uppsala, Sweden. Allan Linneberg Center for Clinical Research and Prevention. Bispebjerg and Frederiksberg Hospital. Frederiksberg, Denmark/Department of Clinical Medicine. Faculty of Health and Medical Sciences. University of Copenhagen. Copenhagen, Denmark. Simin Liu Center for Global Cardiometabolic Health. Departments of Epidemiology, Medicine and Surgery. Brown University. Providence, USA. Peter W. MacFarlane Institute of Health and Wellbeing. College of Medical. Veterinary and Life Sciences. University of Glasgow. Glasgow, UK. Massimo Mangino Department of Twin Research and Genetic Epidemiology. King’s College London. London, UK/NIHR Biomedical Research Centre at Guy’s and St Thomas’ Foundation Trust. London, UK. Thomas Meitinger Institute of Genetic Epidemiology. Helmholtz Zentrum München - German Research Center for Environmental Health. Neuherberg, Germany/Institute of Human Genetics. Technical University of Munich. Munich, Germany/German Centre for Cardiovascular Research, partner site. Munich Heart Alliance. Munich, Germany Massimo Mezzavilla Institute for Maternal and Child Health – IRCCS “Burlo Garofolo”. Trieste, Italy. Pashupati P. Mishra Department of Clinical Chemistry. Fimlab Laboratories. Tampere, Finland/Department of Clinical Chemistry. Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology. Tampere University. Tampere, Finland. Rebecca N. Mitchell8 McKusick‐Nathans Institute. Department of Genetic Medicine. Johns Hopkins University. School of Medicine. Baltimore, MD, USA. Nina Mononen Department of Clinical Chemistry. Fimlab Laboratories. Tampere, Finland/Department of Clinical Chemistry. Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology. Tampere University. Tampere, Finland. May E. Montasser Division of Endocrinology, Diabetes, and Nutrition. University of Maryland School of Medicine. Baltimore, MD, USA/ Program for Personalized and Genomic Medicine. University of Maryland School of Medicine. Baltimore, MD, USA. Alanna C. Morrison Human Genetics Center. Department of Epidemiology. Human Genetics, and Environmental Sciences. School of Public Health. The University of Texas Health Science Center at Houston. Houston, TX, USA. Matthias Nauck DZHK German Centre for Cardiovascular Research; partner site Greifswald, Greifswald, Germany/ Institute of Clinical Chemistry and Laboratory Medicine. University Medicine Greifswald. Greifswald, Germany. Victor Nauffal Cardiovascular Disease Initiative. Broad Institute. Cambridge, MA, USA/Division of Cardiovascular Medicine. Brigham and Women’s Hospital. Boston, MA, USA. Pau Navarro MRC Human Genetics Unit. Institute of Genetics and Cancer. University of Edinburgh. Edinburgh, Scotland. Kjell Nikus Department of Cardiology. Heart Center. Tampere University Hospital. Tampere, Finland/Department of Cardiology. Finnish Cardiovascular Research Center – Tampere. Faculty of Medicine and Health Technology. Tampere University. Tampere, Finland. Guillaume Pare Population Health Research Institute. McMaster University. Hamilton, Canada. Kristen K. Patton Cardiovascular Health Research Unit. Department of Medicine. University of Washington. Seattle, WA, USA. Giulia Pelliccione Institute for Maternal and Child Health – IRCCS “Burlo Garofolo”. Trieste, Italy. Alan Pittman Genetics Research Centre. St George’s University of London. London, UK. David J. Porteous Centre for Genomic and Experimental Medicine. Institute of Genetics and Cancer. University of Edinburgh. Western General Hospital. Edinburgh, UK/ Centre for Cognitive Ageing and Cognitive Epidemiology. University of Edinburgh. Edinburgh, UK. Peter P. Pramstaller Eurac Research. Institute for Biomedicine affiliated with the University of Lübeck. Bolzano, Italy/ Department of Neurology. University of Lübeck. Lübeck, Germany. Michael H. Preuss The Charles Bronfman Institute for Personalized Medicine. Icahn School of Medicine at Mount Sinai. New York, NY, USA. Olli T. Raitakari Centre for Population Health Research. University of Turku and Turku University Hospital. Turku, Finland/Research Centre of Applied and Preventive Cardiovascular Medicine. University of Turku. Turku, Finland/Department of Clinical Physiology and Nuclear Medicine. Turku University Hospital. Turku, Finland. Alexander P. Reiner Department of Epidemiology/University of Washington. Seattle, WA, USA/Fred Hutchinson Cancer Center. University of Washington. Seattle, WA, USA. Antonio Luiz P. Ribeiro Department of Internal Medicine. Faculdade de Medicina. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil/Cardiology Service and Telehealth Center. Hospital das Clínicas. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil. Kenneth M. Rice Department of Biostatistics. University of Washington. Seattle, WA, USA. Lorenz Risch Labormedizinisches zentrum Dr. Risch, Vaduz. Liechtenstein/Faculty of Medical Sciences. Private University in the Principality of Liechtenstein. Triesen, Liechtenstein/Center of Laboratory Medicine. University Institute of Clinical Chemistry. University of Bern. Inselspital, Bern, Switzerland. David Schlessinger Laboratory of Genetics and Genomics. National Institute on Aging. National Institute of Health. Baltimore, US. Ulrich Schotten Deptartment of Physiology. Cardiovascular Research Institute Maastricht CARIM. Maastricht University. Maastricht, The Netherlands. Claudia Schurmann The Charles Bronfman Institute for Personalized Medicine. Icahn School of Medicine at Mount Sinai. New York, NY, USA/ Digital Health Center. Hasso Plattner Institute. University of Potsdam, Potsdam. Germany/Hasso Plattner Institute for Digital Health at Mount Sinai. Icahn School of Medicine at Mount Sinai. New York, NY, USA. Xia Shen Centre for Global Health Research. Usher Institute. University of Edinburgh. Edinburgh, Scotland/Department of Medical Epidemiology and Biostatistics. Karolinska Institutet. Stockholm, Sweden/Greater Bay Area Institute of Precision Medicine Guangzhou. Fudan University. Nansha District, Guangzhou, China. M. Benjamin Shoemaker Department of Medicine. Division of Cardiovascular Medicine. Arrhythmia Section. Vanderbilt University Medical Center. Nashville, TN, USA. Gianfranco Sinagra Cardiothoracovascular Department. University of Trieste. Trieste, Italy. Moritz F. Sinner Department of Cardiology. University Hospital. LMU Munich, Munich, Germany/ German Centre for Cardiovascular Research, partner site. Munich Heart Alliance. Munich, Germany. Elsayed Z. Soliman Epidemiological Cardiology Research Center EPICARE. Wake Forest School of Medicine. Winston Salem, USA. Monika Stoll Maastricht Center for Systems Biology MaCSBio. Maastricht University. Maastricht, The Netherlands/Dept. of Biochemistry. Cardiovascular Research Institute Maastricht CARIM. Maastricht University. Maastricht, NL, The Netherlands/Institute of Human Genetics. Genetic Epidemiology. University of Muenster. Muenster, Germany. Konstantin Strauch Institute of Genetic Epidemiology. Helmholtz Zentrum München - German Research Center for Environmental Health. Neuherberg, Germany/ IBE. Faculty of Medicine. LMU Munich, Munich, Germany/Institute of Medical Biostatistics. Epidemiology and Informatics IMBEI. University Medical Center. Johannes Gutenberg University. Mainz, Germany. Kirill Tarasov Laboratory of Cardiovascular Sciences. National Institute on Aging. National Institute of Health. Baltimore, US. Kent D. Taylor Institute for Translational Genomics and Population Sciences/The Lundquist Institute at Harbor-UCLA Medical Center. Torrance, CA, USA/ Department of Pediatrics/Harbor-UCLA Medical Center. Torrance, CA, USA/Department of Pediatrics/David Geffen School of Medicine at UCLA. Los Angeles, CA, USA. Andrew Tinker William Harvey Research Institute. Clinical Pharmacology. Queen Mary University of London. London, UK/ NIHR Barts Cardiovascular Biomedical Research Centre. Barts and The London School of Medicine and Dentistry. Queen Mary University of London. London, UK. Stella Trompet Department of Internal Medicine. section of Gerontology and Geriatrics. Leiden University Medical Center. Leiden, The Netherlands/ Department of Cardiology. Leiden University Medical Center. Leiden, The Netherlands. André Uitterlinden Internal Medicine. Erasmus MC. Rotterdam, The Netherlands. Uwe Völker DZHK German Centre for Cardiovascular Research; partner site Greifswald, Greifswald, Germany/Interfaculty Institute for Genetics and Functional Genomics. Department of Functional Genomics. University Medicine Greifswald. Greifswald, Germany. Henry Völzke DZHK German Centre for Cardiovascular Research; partner site Greifswald, Greifswald, Germany/ Institute for Community Medicine. University Medicine Greifswald. Greifswald, Germany. Melanie Waldenberger German Centre for Cardiovascular Research, partner site. Munich Heart Alliance. Munich, Germany/Research Unit Molecular Epidemiology. Institute of Epidemiology. Helmholtz Zentrum München - German Research Center for Environmental Health. Neuherberg, Germany. Lu-Chen Weng Cardiovascular Disease Initiative. Broad Institute. Cambridge, MA, USA/ Cardiovascular Research Center. Massachusetts General Hospital. Boston, MA, USA. Eric A. Whitsel Department of Epidemiology. Gillings School of Global Public Health. University of North Carolina at Chapel Hill. Chapel Hill, USA/Department of Medicine. School of Medicine. University of North Carolina. Chapel Hill, NC, USA. James G. Wilson Department of Physiology and Biophysics. University of Mississippi Medical Center. Jackson, USA/Department of Cardiology. Beth Israel Deaconess Medical Center. Boston, USA. Christy L. Avery Department of Epidemiology. Gillings School of Global Public Health. University of North Carolina at Chapel Hill. Chapel Hill, USA David Conen Population Health Research Institute. McMaster University. Hamilton, Canada. Adolfo Correa Departments of Medicine, Pediatrics and Population Health Science. University of Mississippi Medical Center. Jackson, USA. Francesco Cucca Institute of Genetic and Biomedical Rsearch. Italian National Research Council, Monserrato. Italy. Marcus Dörr DZHK German Centre for Cardiovascular Research; partner site Greifswald, Greifswald, Germany/ Department of Internal Medicine B - Cardiology, Pneumology, Infectious Diseases. Intensive Care Medicine. Greifswald, Germany/University Medicine Greifswald. Greifswald, Germany. Sina A. Gharib Center for Lung Biology. Division of Pulmonary, Critical Care and Sleep Medicine. University of Washington. Seattle, WA, USA. Giorgia Girotto Institute for Maternal and Child Health – IRCCS “Burlo Garofolo”. Trieste, Italy/ Department of Medical Sciences. University of Trieste. Trieste, Italy. Niels Grarup Novo Nordisk Foundation Center for Basic Metabolic Research. Faculty of Health and Medical Sciences. University of Copenhagen. Copenhagen, Denmark. Caroline Hayward MRC Human Genetics Unit. Institute of Genetics and Cancer. University of Edinburgh. Western General Hospital. Edinburgh, UK. Yalda Jamshidi Genetics Research Centre. St George’s University of London. London, UK. Marjo-Riitta Järvelin Center for Life Course Health Research. Faculty of Medicine. University of Oulu. Oulu, Finland/ Unit of Primary Health Care. Oulu University Hospital. Oulu, Finland/Department of Epidemiology and Biostatistics. MRC PHE Centre for Environment and Health. School of Public Health. Imperial College London. London, UK/Department of Life Sciences. College of Health and Life Sciences. Brunel University London. London, UK. J. Wouter Jukema Department of Cardiology. Leiden University Medical Center. Leiden, The Netherlands/Netherlands Heart Institute. Utrecht, The Netherlands. Stefan Kääb Department of Cardiology. University Hospital. LMU Munich, Munich, Germany/ German Centre for Cardiovascular Research, partner site. Munich Heart Alliance. Munich, Germany. Mika Kähönen Department of Clinical Physiology Tampere University Hospital. Tampere, Finland/Department of Clinical Physiology. Finnish Cardiovascular Research Center – Tampere. Faculty of Medicine and Health Technology. Tampere University. Tampere, Finland. Jørgen K. Kanters Laboratory of Experimental Cardiology. Department of Biomedical Sciences. University of Copenhagen. Copenhagen, Denmark. Charles Kooperberg Public Health Sciences Division. Fred Hutchinson Cancer Center. Seattle, WA, USA. Terho Lehtimäki Department of Clinical Chemistry. Fimlab Laboratories. Tampere, Finland/Department of Clinical Chemistry. Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology. Tampere University. Tampere, Finland. Yongmei Liu Department of Medicine. Duke University. Durham, NC, USA. Ruth J. F. Loos The Charles Bronfman Institute for Personalized Medicine. Icahn School of Medicine at Mount Sinai. New York, NY, USA/The Mindich Child Health and Development Institute. Icahn School of Medicine at Mount Sinai. New York, NY, USA. Steven A. Lubitz Cardiovascular Disease Initiative. Broad Institute. Cambridge, MA, USA/ Demoulas Center for Cardiac Arrhythmias and Cardiovascular Research Center. Massachusetts General Hospital, Boston, MA, USA. Dennis O. Mook-Kanamori Department of Clinical Epidemiology. Leiden University Medical Center. Leiden, The Netherlands/Department of Public Health and Primary Care. Leiden University Medical Center. Leiden, The Netherlands. Andrew P. Morris Department of Health Data Science. University of Liverpool. Liverpool, UK/Centre for Genetics and Genomics Versus Arthritis. Centre for Musculoskeletal Research. The University of Manchester. Manchester, UK/Wellcome Centre for Human Genetics. University of Oxford. Oxford, UK. Jeffrey R. O’Connell Division of Endocrinology, Diabetes, and Nutrition. University of Maryland School of Medicine. Baltimore, MD, USA/Program for Personalized and Genomic Medicine. University of Maryland School of Medicine. Baltimore, MD, USA. Morten Salling Olesen Department of Biomedical Sciences. University of Copenhagen. Copenhagen, Denmark. Michele Orini Barts Heart Centre, St Bartholomew’s Hospital. Barts Health NHS trust. London, UK./ Institute of Cardiovascular Sciences. University of College London. London, UK. Sandosh Padmanabhan Institute of Cardiovascular and Medical Sciences. University of Glasgow. Glasgow, UK. Cristian Pattaro Eurac Research. Institute for Biomedicine affiliated with the University of Lübeck. Bolzano, Italy. Annette Peters Institute of Genetic Epidemiology. Helmholtz Zentrum München - German Research Center for Environmental Health. Neuherberg, Germany/ German Centre for Cardiovascular Research, partner site. Munich Heart Alliance. Munich, Germany. Bruce M. Psaty Cardiovascular Health Research Unit. Department of Medicine. University of Washington. Seattle, WA, USA/ Department of Epidemiology/University of Washington. Seattle, WA, USA/ Health Systems and Population Health. University of Washington. Seattle, WA, USA. Jerome I. Rotter Institute for Translational Genomics and Population Sciences/The Lundquist Institute at Harbor-UCLA Medical Center. Torrance, CA, USA/Department of Pediatrics/Harbor-UCLA Medical Center. Torrance, CA, USA/Departments of Pediatrics and Human Genetics/David Geffen School of Medicine at UCLA. Los Angeles, CA, USA. Bruno Stricker Department of Epidemiology. Erasmus MC – University Medical Center. Rotterdam, The Netherlands. Pim van der Harst University of Groningen. University Medical Center Groningen. Department of Cardiology. Groningen, The Netherlands/ Department of Cardiology. Heart and Lung Division. University Medical Center Utrecht. Utrecht, The Netherlands. Xornelia M. van Duijn Nuffield Department of Population Health. University of Oxford. Oxford, UK/Department of Epidemiology. Erasmus MC University Medical Center. Rotterdam, The Netherlands. Niek Verweij University of Groningen. University Medical Center Groningen. Department of Cardiology. Groningen, The Netherlands James F. Wilson Centre for Global Health Research. Usher Institute. University of Edinburgh. Edinburgh, Scotland/MRC Human Genetics Unit. Institute of Genetics and Cancer. University of Edinburgh. Edinburgh, Scotland. Dan E. Arking McKusick‐Nathans Institute. Department of Genetic Medicine. Johns Hopkins University. School of Medicine. Baltimore, MD, USA. Julia Ramirez William Harvey Research Institute. Clinical Pharmacology. Queen Mary University of London. London, UK/ Institute of Cardiovascular Sciences. University of College London. London, UK. Pier D. Lambiase Barts Heart Centre, St Bartholomew’s Hospital. Barts Health NHS trust. London, UK/ Institute of Cardiovascular Sciences. University of College London. London, UK. Nona Sotoodehnia Cardiovascular Health Research Unit. Division of Cardiology. Department of Medicine, University of Washington. Seattle, WA, USA. Borbala Mifsud William Harvey Research Institute. Clinical Pharmacology. Queen Mary University of London. London, UK/Genomics and Translational Biomedicine. College of Health and Life Sciences. Hamad Bin Khalifa University. Doha, Qatar Christopher Newton-Cheh Program in Medical and Population Genetics. Broad Institute of Harvard and MIT.Cambridge, MA, USA/Cardiovascular Research Center. Center for Genomic Medicine. Massachusetts General Hospital. Boston, MA, USA. Patricia B. Munroe Barts Heart Centre, St Bartholomew’s Hospital. Barts Health NHS trust. London, UK/ NIHR Barts Cardiovascular Biomedical Research Centre. Barts and The London School of Medicine and Dentistry. Queen Mary University of London. London, UK.The QT interval is an electrocardiographic measure representing the sum of ventricular depolarization (QRS duration) and repolarization (JT interval). Abnormalities of the QT interval are associated with potentially fatal ventricular arrhythmia. We conducted genome-wide multi-ancestry analyses in >250,000 individuals and identified 177, 156 and 121 independent loci for QT, JT and QRS, respectively, including a male-specific X-chromosome locus. Using gene-based rare-variant methods, we identified associations with Mendelian disease genes. Enrichments were observed in established pathways for QT and JT, with new genes indicated in insulin-receptor signalling and cardiac energy metabolism. In contrast, connective tissue components and processes for cell growth and extracellular matrix interactions were significantly enriched for QRS. We demonstrate polygenic risk score associations with atrial fibrillation, conduction disease and sudden cardiac death. Prioritization of druggable genes highlighted potential therapeutic targets for arrhythmia. Together, these results substantially advance our understanding of the genetic architecture of ventricular depolarization and repolarization.