Article
Association of Sicca Syndrome with Proviral Load and Proinflammatory Cytokines in HTLV-1 Infection
Registro en:
LIMA, C. M. et al. Association of Sicca Syndrome with Proviral Load and Proinflammatory Cytokines in HTLV-1 Infection. Journal of Immunology Research, article ID 8402059, 2016.
2314-8861
10.1155/2016/8402059
Autor
Lima, Clara Mônica
Santos, Silvane Maria Braga
Dourado, Adriana
Carvalho, Natália Barbosa
Bittencourt, Valéria
Lessa, Marcus Miranda
Siqueira, Isadora Cristina de
Carvalho Filho, Edgar Marcelino
Resumen
The Sjögren syndrome has been diagnosed in patients with HTLV-1 associated myelopathy and dry mouth and dry eyes are documented in HTLV-1 carriers. However the diagnosis of Sjögren syndrome in these subjects has been contested. In this cross-sectional study, we evaluated the role of immunological factors and proviral load, in sicca syndrome associated with HTLV-1 in patients without myelopathy. Subjects were recruited in the HTLV-1 Clinic, from 2009 to 2011. The proviral load and cytokine levels (IFN-γ, TNF-α, IL-5, and IL-10) were obtained from a database containing the values presented by the subjects at admission in the clinic. Of the 272 participants, 59 (21.7%) had sicca syndrome and in all of them anti-Sjögren syndrome related antigen A (SSA) and antigen B (SSB) were negatives. The production of TNF-α and IFN-γ was higher in the group with sicca syndrome (P < 0.05) than in HTLV-1 infected subjects without sicca syndrome. Our data indicates that patients with sicca syndrome associated with HTLV-1 do not have Sjögren syndrome. However the increased production of TNF-α and IFN-γ in this group of patients may contribute to the pathogenesis of sicca syndrome associated with HTLV-1.