dc.creator | Hidalgo, Núria Fernández | |
dc.creator | Gharamti, Amal A. | |
dc.creator | Aznar, María Luisa | |
dc.creator | Almirante, Benito | |
dc.creator | Yasmin, Mohamad | |
dc.creator | Fortes, Claudio Querido | |
dc.creator | Plesiat, Patrick | |
dc.creator | Doco-Lecompte, Thanh | |
dc.creator | Rizk, Hussein | |
dc.creator | Wray, Dannah | |
dc.creator | Lamas, Cristiane | |
dc.creator | Durante-Mangoni, Emanuele | |
dc.creator | Tattevin, Pierre | |
dc.creator | Snygg-Martin, Ulrika | |
dc.creator | Hannan, Margaret M. | |
dc.creator | Chu, Vivian H. | |
dc.creator | Kanafani, Zeina A. | |
dc.date | 2021-03-24T21:01:11Z | |
dc.date | 2021-03-24T21:01:11Z | |
dc.date | 2020 | |
dc.date.accessioned | 2023-09-26T20:10:16Z | |
dc.date.available | 2023-09-26T20:10:16Z | |
dc.identifier | HIDALGO, Núria Fernández et al. Beta-Hemolytic Streptococcal Infective Endocarditis: Characteristics and Outcomes From a Large, Multinational Cohort. Open forum infectious diseases, v. 7, n. 5, p. 1-9, 2020 | |
dc.identifier | 2328-8957 | |
dc.identifier | https://www.arca.fiocruz.br/handle/icict/46432 | |
dc.identifier | 10.1093/ofid/ofaa120 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8850325 | |
dc.description | Cristiane Lamas. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento. | |
dc.description | Background: Beta-hemolytic streptococci (BHS) are an uncommon cause of infective endocarditis (IE). The aim of this study was to describe the clinical features and outcomes of patients with BHS IE in a large multinational cohort and compare them with patients with viridans streptococcal IE.
Methods: The International Collaboration on Endocarditis Prospective Cohort Study (ICE-PCS) is a large multinational database that recruited patients with IE prospectively using a standardized data set. Sixty-four sites in 28 countries reported patients prospectively using a standard case report form developed by ICE collaborators.
Results: Among 1336 definite cases of streptococcal IE, 823 were caused by VGS and 147 by BHS. Patients with BHS IE had a lower prevalence of native valve (P < .005) and congenital heart disease predisposition (P = .002), but higher prevalence of implantable cardiac device predisposition (P < .005). Clinically, they were more likely to present acutely (P < .005) and with fever (P = .024). BHS IE was more likely to be complicated by stroke and other systemic emboli (P < .005). The overall in-hospital mortality of BHS IE was significantly higher than that of VGS IE (P = .001). In univariate analysis, variables associated with in-hospital mortality for BHS IE were age (odds ratio [OR], 1.044; P = .004), prosthetic valve IE (OR, 3.029; P = .022), congestive heart failure (OR, 2.513; P = .034), and stroke (OR, 3.198; P = .009).
Conclusions: BHS IE is characterized by an acute presentation and higher rate of stroke, systemic emboli, and in-hospital mortality than VGS IE. Implantable cardiac devices as a predisposing factor were more often found in BHS IE compared with VGS IE. | |
dc.format | application/pdf | |
dc.language | eng | |
dc.publisher | Oxford | |
dc.rights | restricted access | |
dc.subject | International Collaboration on Endocarditis | |
dc.subject | Beta-hemolytic streptococci | |
dc.subject | Cardiac devices | |
dc.subject | Congestive heart failure | |
dc.subject | Infective endocarditis | |
dc.title | Beta-hemolytic streptococcal infective endocarditis: Characteristics and outcomes from a large, multinational cohort | |
dc.type | Article | |