Article
Activity of a paromomycin hydrophilic formulation for topical treatment of infections by Leishmania (Leishmania) amazonensis and Leishmania (Viannia) braziliensis
Registro en:
GONÇALVES, Gisele Santos et al. Activity of a paromomycin hydrophilic formulation for topical treatment of infections by Leishmania (Leishmania) amazonensis and Leishmania (Viannia) braziliensis. Acta Trop., v. 93, n. 2, p. 161-167, Feb. 2005.
0001-706X
Autor
Gonçalves, Gisele Santos
Fernandes, Ana Paula
Souza, Renata Celi Carvalho
Cardoso, Jarbas Eustaquio
Silva, Fernanda de Oliveira
Maciel, Fabiana Cristina
Rabello, Ana Lúcia Teles
Ferreira, Lucas Antonio Miranda
Resumen
Studies on in vitro skin permeation and in vivo anti-leishmanial activity in mice experimentally infected with Leishmania (Leishmania) majorpointed out to the potential of a new paromomycin (PA) formulation (hydrophilic gel) for treatment of cutaneous leishmaniasis (CL). In this study, the activity of this formulation was evaluated in animals experimentally infected by Leishmaniaspecies that prevail in the New World. PA gel activity was compared to antimony treatment, since it is still the first choice treatment to the different clinical forms of leishmaniasis. The topical treatment activity with 10% PA gel in BALB/c mice infected by Leishmania(Leishmania)amazonensiswas higher than that observed for parenteral antimony treatment, while the efficacy of these two regimes in hamsters infected byLeishmania(Viannia)braziliensiswas similar. These results suggest that this formulation could be suitable for clinical studies and may represent an alternative novel formulation for topical treatment of CL.