Article
Adult T-cell leukemia/lymphoma in northeastern Brazil: a clinical, histopathologic, and molecular study
Registro en:
BARBOSA, Helenemarie Schaer et al. Adult T-cell leukemia/lymphoma in northeastern Brazil: a clinical, histopathologic, and molecular study. Journal of Acquired Immune Deficiency Syndromes, v. 21, n. 1, p. 65-71, 1999.
1525-4135
Autor
Barbosa, Helenemarie Schaer
Bittencourt, Achilea Candida Lisboa
Araújo, Iguaracyra Barreto de Oliveira
Pereira Filho, Carlos Sampaio
Furlan, Roberto
Pedrosa, Célia
Lessa, Gildete
Harrington Junior, William
Castro Filho, Bernardo Galvão
Resumen
The state of Bahia in the northeastern coast of Brazil is a region in which HTLV-I infection is endemic. This study investigated the characteristics of 28 HTLV-I-associated lymphomas/leukemias in this region. HTLV-I-infection diagnosis was based on serologic study, Southern blot analysis, and polymerase chain reaction (PCR) in neoplastic tissue. The main clinical differences between these lymphomas and adult T-cell leukemia (ATL) cases from other endemic areas were as follows. The mean age was 47 years; 20% of the cases occurred in young adults; and a predominance was found among male subjects (2:1), blacks, and of those of mixed race (96%). Histologically, 20 cases were T-cell pleomorphic leukemia/lymphoma, 5 were Mycosis fungoides-like cutaneous lymphoma, and 3 were CD30+ large-cell anaplastic lymphoma. Immunohistochemistry demonstrated 4 cases of CD8+ lymphoma. Proviral genomic sequences were demonstrated by PCR in 9 lymph node biopsy specimens and in 3 skin biopsy specimens. Southern blot was performed and was positive in 8 cases.