Article
Portal vein embolization with n-butyl-cyanoacrylate through an ipsilateral approach before major hepatectomy: single center analysis of 50 consecutive patients
Registro en:
LUZ, José Hugo Mendes, et al. Portal vein embolization with n-butylcyanoacrylate through an ipsilateral approach before major hepatectomy: single center analysis of 50 consecutive patients. Cancer Imaging, v. 17, n. 25, 2017.
1470-7330
10.1186/s40644-017-0127-3
Autor
Luz, José Hugo Mendes
Luz, Paula Mendes
Bilhim, Tiago
Martin, Henrique Salas
Gouveia, Hugo Rodrigues
Coimbra, Élia
Gomes, Filipe Veloso
Souza, Roberto Romulo
Faria, Igor Murad
de Miranda, Tiago Nepomuceno
Resumen
Purpose: To evaluate the efficacy of portal vein embolization (PVE) with n-Butyl-cyanoacrylate (NBCA) through
an ipsilateral approach before major hepatectomy. Secondary end-points were PVE safety, liver resection and
patient outcome. Methods: Over a 5-year period 50 non-cirrhotic consecutive patients were included with primary or secondary liver cancer treatable by hepatectomy with a liver remnant (FLR) volume less than 25% or less than 40% in diseased livers. Results: There were 37 men and 13 women with a mean age of 57 years. Colorectal liver metastases were the most frequent tumor and patients were previously exposed to chemotherapy. FLR increased from 422 ml to 629 ml (P < 0.001) after PVE, corresponding to anincrease of 52%. The FLR ratio increased from 29.6% to 42.3% (P < 0.001). Kinetic growth rate was 2.98%/week. A negative association was observed between increase in the FLR and FLR ratio and FLR volume before PVE (P = 0.002). In 31 patients hepatectomy was accomplished and only one patient presented with liver insufficiency within 30 days after surgery. Conclusions: PVE with NBCA through an ipsilateral puncture is effective before major hepatectomy. Meticulous attention is needed especially near the end of the embolization procedure to avoid complications.