Article
The role of methylenetetrahydrofolate reductase in acute lymphoblastic leukemia in a Brazilian mixed population
Registro en:
ZANROSSO, Crisiane Wais et al. The role of methylenetetrahydrofolate reductase in acute lymphoblastic leukemia in a Brazilian mixed population. Leukemia Research, v. 30, p. 477-481, 2006.
0145-2126
10.1016/j.leukres.2005.08.008
1873-5835
Autor
Zanrosso, Crisiane Wais
Hatagima, Ana
Emerenciano, Mariana
Ramos, Flávio
Figueiredo, Alexandre
Féliz, Têmis Maria
Segal, Sandra L.
Guigliani, Roberto
Muniz, Maria Tereza Cartaxo
Oliveira, Maria S. Pombo de
Resumen
The polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene are associated with leukemogenesis. In order to investigate
the influence of two polymorphisms in the MTHFR gene, 677C > T and 1298A >C, on the risk of acute lymphoblastic leukemia (ALL) we
performed a case–control study in children from different Brazilians’ regions. Genotyping of 176 ALL and 199 unselected healthy subjects
was performed using PCR-RFLP assay. There was no association between the 677C > T or 1298A >C and risk of ALL in total case–control
sample. However, 677T allele was linked to a decrease risk of ALL [odds ratio (OR), 0.43; 95% confidence interval (CI), 0.22–0.86], whereas
the 1298A >C polymorphism presents an elevated risk factor [OR, 2.01; 95% CI, 1.01–3.99] in non-White children. Our investigation provides
interesting data concerning the opposite effect of A1298C polymorphisms, particularly in the light of relatively scarce data regarding the
MTHFR role in leukemia susceptibility in different populations. 2025-01-01