Article
Prevalence and clinical implications of low-risk human papillomavirus among patients with recurrent respiratory papillomatosis in Rio de Janeiro, Brazil
Registro en:
FIGUEIREDO, Marcelo Cardoso et al. Prevalence and clinical implications of low-risk human papillomavirus among patients with recurrent respiratory papillomatosis in Rio de Janeiro, Brazil. Auris Nasus Larynx, v. 46, p. 570-575, 2019.
0385-8146
10.1016/j.anl.2018.11.014
1879-1476
Autor
Figueiredo, Marcelo Cardoso
Justino, Mariana Chantre
Delmonico, Lucas
Silvestre, Rafaele Tavares
Castro, Thiago Luz de
Moreira, Aline dos Santos
Macedo, Jacyara Maria Brito
Carvalho, Maria da Glória da Costa
Scherrer, Luciano
Lima, Daniel José Matos de Medeiros
Alves, Gilda
Ornellas, Maria Helena
Resumen
Objective: The aim of this study was to investigate the presence of human papillomavirus (HPV) in biopsy specimens from juvenile and adult patients with histopathological diagnosis of recurrent respiratory papillomatosis (RRP) treated in two public hospitals in Rio de Janeiro, Brazil. Methods: We performed the detection and genotyping of HPV by PCR technique for the types 6, 11, 16, and 18 in biopsy specimens from 41 RRP patients.
Results: The juvenile onset RRP (JoRRP) corresponded to 61% and the adult onset RRP (AoRRP) corresponded to 39% of the study group. Prevalence of males was observed in both the adult (81.3%) and the juvenile (56%) groups. Lesions in the larynx were more frequent in the glottis (46%). Genotyping analysis only revealed patients with HPV-6 (34.1%), HPV-11(17.1%), and coinfection HPV-6 and -11 (48.8%). RRP severity was significantly associated with the JoRRP (p < 0.001), with extralaryngeal disease and more surgeries. However, no significant association between RRP severity and HPV types was found. One co-infected patient in the JoRRP died due to the evolution of the disease with lung involvement. Conclusion: These results show the strong association of HPV-6 and/or HPV-11 types with RRP and could complement the diagnosis, prognosis, and therapies for these patients. In addition, the HPV vaccination should be encouraged to prevent the disease. 2025-01-01