Article
Toll-Like Receptor-2-Mediated C-C Chemokine Receptor 3 and Eotaxin-Driven Eosinophil Influx Induced by Mycobacterium bovis BCG Pleurisy
Registro en:
D`ÁVILA, Heloisa et al. Toll-Like Receptor-2-Mediated C-C Chemokine Receptor 3 and Eotaxin-Driven Eosinophil Influx Induced by Mycobacterium bovis BCG Pleurisy. Infection and Immunity, v. 75, n. 3, p. 1507-1522, Mar. 2007.
0019-9567
10.1128/IAI.01326-06
1098-5522
Autor
D'Avila, Heloisa
Almeida, Patrícia E.
Roque, Natália R.
Faria Neto, Hugo Caire C.
Bozza, Patrícia T.
Resumen
Acesso aberto em 20/04/2020 - https://iai.asm.org/content/iai/75/3/1507.full.pdf An acute and persistent eosinophil infiltration is observed during Mycobacterium bovis BCG pleural infection in mice. Eosinophil accumulation, lipid body formation, and eotaxin production were significantly reduced in BCG-infected Toll-like receptor-2 (TLR2)-deficient mice compared to wild-type mice. Neutralization of eotaxin or CCR3 drastically inhibited BCG-induced eosinophil accumulation and lipid body formation, indicating that BCG-induced eosinophil recruitment and activation is largely dependent of TLR2-mediated eotaxin generation. 2020-01-01