Otro
Calcium-Independent Membrane Damage by Venom Phospholipases A(2)
Registro en:
Protein and Peptide Letters. Sharjah: Bentham Science Publ Ltd, v. 16, n. 8, p. 877-886, 2009.
0929-8665
WOS:000268890600004
Autor
de Oliveira, A. H. C.
Aragao, E. A.
Sa, J. M.
Chioato, L.
Bugs-Bortoleto, R.
Ruller, R.
Ferreira, T. L.
Ward, R. J.
Resumen
Many snake venom phospholipase A(2)s (vPLA(2)s) present biological effects that are independent of hydrolytic activity. Here we review the evidence for the calcium-independent membrane damaging activity of vPLA(2)s, the possible relevance of this activity on their biological effects, and models for the mechanism of membrane permeabilization by these proteins. Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)