Small interfering RNA for cancer treatment: overcoming hurdles in delivery

dc.creatorZacconi, Flavia C. M.
dc.creatorAljabali, Alaa A.A.
dc.creatorChellappan, D.K.
dc.creatorShrivastava, Garima
dc.creatorGupta, Gaurav
dc.creatorBakshi, Hamid A.
dc.creatorDua, Kamal
dc.creatorMetha, Meenu
dc.creatorTambuwala, Murtaza M.
dc.creatorAmnerkar, Nikhil D.
dc.creatorCharbe, Nitin Bharat
dc.creatorNegi, Poonam
dc.creatorSatheeshkumar, Rajendran
dc.creatorKhadse, Saurabh C.
dc.creatorSatija, Saurabh
dc.date.accessioned2023-08-23T21:36:24Z
dc.date.available2023-08-23T21:36:24Z
dc.date.created2023-08-23T21:36:24Z
dc.date.issued2020
dc.identifierNitin Bharat Charbe, Nikhil D. Amnerkar, Murtaza M. Tambuwala, Hamid A. Bakshi, Alaa A.A. Aljabali, Saurabh C. Khadse, Rajendran Satheeshkumar, Saurabh Satija, Meenu Metha, Dinesh Kumar Chellappan, Garima Shrivastava, Gaurav Gupta, Poonam Negi, Kamal Dua, Flavia C. Zacconi. Small interfering RNA for cancer treatment: overcoming hurdles in delivery. Science. 2020;(10005):1-1.
dc.identifier10.1016/j.apsb.2020.10.005
dc.identifier2211-3835
dc.identifierhttps://doi.org/10.1016/j.apsb.2020.10.005
dc.identifierhttps://repositorio.uc.cl/handle/11534/74483
dc.identifierWOS:000595499500005
dc.description.abstractIn many ways, cancer cells are different from healthy cells. A lot of tactical nano-based drug delivery systems are based on the difference between cancer and healthy cells. Currently, nanotechnology-based delivery systems are the most promising tool to deliver DNA-based products to cancer cells. This review aims to highlight the latest development in the lipids and polymeric nanocarrier for siRNA delivery to the cancer cells. It also provides the necessary information about siRNA development and its mechanism of action. Overall, this review gives us a clear picture of lipid and polymer-based drug delivery systems, which in the future could form the base to translate the basic siRNA biology into siRNA-based cancer therapies. (C) 2020 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
dc.languageen
dc.rightsacceso abierto
dc.subjectSmall interfering RNA (siRNA)
dc.subjectNanomedicine
dc.subjectLiposomes
dc.subjectMicelles
dc.subjectCancer
dc.subjectPolymer
dc.titleSmall interfering RNA for cancer treatment: overcoming hurdles in delivery
dc.typeartículo


Este ítem pertenece a la siguiente institución