Artigo
TNF-alpha and IL-6 immunohistochemistry in rat renal tissue experimentaly infected with Leptospira interrogans serovar Canicola
Registro en:
Journal of Venomous Animals and Toxins Including Tropical Diseases. Botucatu: Cevap-unesp, v. 14, n. 3, p. 533-540, 2008.
1678-9199
10.1590/S1678-91992008000300012
S1678-91992008000300012
WOS:000259279500012
2-s2.0-52249107118
S1678-91992008000300012-en.pdf
5071093931017493
6586331343354343
2976129874554698
0310405558125634
Autor
Marinho, Márcia [UNESP]
Monteiro, Cristina Maria Rodrigues [UNESP]
Peiró, Juliana Regina [UNESP]
Machado, Gisele Fabrino [UNESP]
Oliveira-Junior, I. S.
Resumen
Leptospirosis is a public health problem worldwide and its etiology remains unclear. Its pathogenesis involves a complex interaction between host and infecting microorganism. The inflammatory reaction that controls the infection process also underscores many pathophysiological events occurring in leptospirosis. We investigated the presence of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in renal tissues by immunohistochemical and histopathological examination in animals experimentally inoculated with Leptospira serovar Canicola. All the tests were carried out 2, 7, 14, 21 or 28 days after inoculation. Although TNF-alpha and IL-6 had been detected in tissues throughout the observation period, these cytokines appeared more intensely during the initial phase of infection. Therefore, both TNF-alpha and IL-6 were associated with the immunopathogenesis of leptospirosis. This profile suggests a high immunocellular response throughout the early infection stages followed by subsequent humoral response. Univ Estadual Paulista, Sch Dent, FOA, Dept Anim Hlth & Prod, BR-16050680 Aracatuba, SP, Brazil Univ Estadual Paulista, Sch Dent, FOA, Dept Clin Surg & Anim Reprod, BR-16050680 Aracatuba, SP, Brazil Univ Fed São Paulo, Dept Med, Div Geriatr & Gerontol, Inflammatory Mediators Lab, São Paulo, Brazil Univ Estadual Paulista, Sch Dent, FOA, Dept Anim Hlth & Prod, BR-16050680 Aracatuba, SP, Brazil Univ Estadual Paulista, Sch Dent, FOA, Dept Clin Surg & Anim Reprod, BR-16050680 Aracatuba, SP, Brazil