| dc.contributor | Universidade Estadual Paulista (Unesp) | |
| dc.contributor | Universidade Estadual de Campinas (UNICAMP) | |
| dc.contributor | Universidade de São Paulo (USP) | |
| dc.creator | Eleuterio, Nibia Mariana [UNESP] | |
| dc.creator | Palei, Ana C. T. | |
| dc.creator | Machado, Jackeline S. Rangel | |
| dc.creator | Tanus-Santos, Jose E. | |
| dc.creator | Cavalli, Ricardo C. | |
| dc.creator | Sandrim, Valeria C. [UNESP] | |
| dc.date | 2015-12-07T15:32:46Z | |
| dc.date | 2015-12-07T15:32:46Z | |
| dc.date | 2015 | |
| dc.date.accessioned | 2023-09-12T07:31:28Z | |
| dc.date.available | 2023-09-12T07:31:28Z | |
| dc.identifier | http://dx.doi.org/10.1016/j.preghy.2015.03.001 | |
| dc.identifier | Pregnancy Hypertension, v. 5, n. 2, p. 205-208, 2015. | |
| dc.identifier | 2210-7797 | |
| dc.identifier | http://hdl.handle.net/11449/131222 | |
| dc.identifier | 10.1016/j.preghy.2015.03.001 | |
| dc.identifier | 25943646 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8780503 | |
| dc.description | The aims of the present study were to compare plasma concentrations of the adiponectin, leptin, metalloproteinases (MMP9 and MMP2) and its tissue inhibitors (TIMP1 and TIMP2) in preeclamptic (PE) and healthy pregnant (HP) groups and correlate them. A total of 105 pregnant women with pre-pregnancy body mass index (BMI) values ⩽ 30 kg/m(2) were enrolled for this study (59 PE and 46 HP). Biomarkers were measured using ELISAs. Adiponectin (32%), leptin (45%), MMP2 (20%), TIMP1 (31%) and TIMP2 (23%) levels were higher in PE compared to HP (all P < 0.05). In addition there were positive correlations between adiponectin and MMP2 (r = 0.33; P = 0.03) and adiponectin and TIMP2 (r = 0.33; P = 0.03) in PE group, but not in HP. Our findings show that adiponectin, leptin, MMP2, TIMP1 and TIMP2 levels are increased in PE and adiponectin may contribute to higher levels of MMP2 and TIMP2 in this disease. | |
| dc.description | Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) | |
| dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
| dc.description | Department of Pharmacology, Institute of Biosciences, Universidade Estadual Paulista (UNESP), Botucatu/SP, Brazil | |
| dc.description | Department of Pharmacology, Faculty of Medicinal Sciences, University of Campinas, State University of Campinas, Campinas/SP, Brazil | |
| dc.description | Department of Gynecology and Obstetrics, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirão Preto/SP, Brazil | |
| dc.description | Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto/SP, Brazil. | |
| dc.description | Department of Pharmacology, Institute of Biosciences, Universidade Estadual Paulista (UNESP), Botucatu/SP, Brazil | |
| dc.description | Department of Pharmacology, Institute of Biosciences, Universidade Estadual Paulista (UNESP), Botucatu/SP, Brazil | |
| dc.description | Department of Pharmacology, Institute of Biosciences, Universidade Estadual Paulista (UNESP), Botucatu/SP, Brazil | |
| dc.format | 205-208 | |
| dc.language | eng | |
| dc.publisher | Elsevier B. V. | |
| dc.relation | Pregnancy Hypertension | |
| dc.rights | Acesso restrito | |
| dc.source | PubMed | |
| dc.subject | Adiponectin | |
| dc.subject | Leptin | |
| dc.subject | Metalloproteinase (mmp)-2 and (mmp)-9 | |
| dc.subject | Preeclampsia | |
| dc.subject | Tissue inhibitor of metalloproteinase (timp)-1 and (timp)-2 | |
| dc.title | Positive correlations between circulating adiponectin and MMP2 in preeclampsia pregnant | |
| dc.type | Artigo | |
