Artigo
The use of a mixture of somatic and culture filtrate antigens in the evaluation of the immune response to Paracoccidioides brasiliensis
Registro en:
Journal of Medical and Veterinary Mycology, v. 29, n. 5, p. 331-334, 1991.
0268-1218
10.1080/02681219180000501
WOS:A1991GH54600007
2-s2.0-0025834460
Autor
Silva, M. I. Correa da
Carvalho, I. Maximo de
Franco, T. N.
Cunha, M. A.
Chamma, L. G.
Fogaca, J.
Fecchio, Denise [UNESP]
Franco, M.
Resumen
Three Paracoccidioides brasiliensis antigens, namely a culture filtrate preparation, a somatic antigen and a mixture of equal parts of the two, were tested by two serological techniques against sera from patients with paracoccidioidomycosis, and in an in vivo delayed hypersensitivity model in mice. The antigen mixture was more sensitive than the two individual antigens for the evaluation of humoral and cellular immune response to P. brasiliensis, both in man and in experimental animals. UNIV ESTADUAL PAULISTA JULIO MESQUITA FILHO, FAC MED, SCH MED,DEPT PATOL, CEP 18610, BOTUCATU, SP, BRAZIL UNIV ESTADUAL PAULISTA JULIO MESQUITA FILHO, FAC MED, SCH MED,DEPT PATOL, CEP 18610, BOTUCATU, SP, BRAZIL