Genotoxic responses of juvenile tilapia (Oreochromis niloticus) exposed to florfenicol and oxytetracycline

dc.contributorUniversidade de São Paulo (USP)
dc.contributorCentro Universitário Hermínio Ometto FHO (UNIARARAS)
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade Estadual da Paraíba (UFPB)
dc.creatorBotelho, R. G.
dc.creatorChristofoletti, C. A.
dc.creatorCorreia, J. E. [UNESP]
dc.creatorAnsoar, Y. [UNESP]
dc.creatorOlinda, R. A.
dc.creatorTornisielo, V. L.
dc.date2015-10-22T07:13:42Z
dc.date2015-10-22T07:13:42Z
dc.date2015-08-01
dc.date.accessioned2023-09-12T07:03:32Z
dc.date.available2023-09-12T07:03:32Z
dc.identifierhttp://www.sciencedirect.com/science/article/pii/S0045653515001678
dc.identifierChemosphere, v. 132, p. 206-212, 2015.
dc.identifier0045-6535
dc.identifierhttp://hdl.handle.net/11449/129815
dc.identifier10.1016/j.chemosphere.2015.02.053
dc.identifierWOS:000355882900029
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8779144
dc.descriptionFlorfenicol (FLC) and oxytetracycline (OTC) are the two most commonly used antibiotics for bacterial treatment in fish farming in Brazil, and because of their intensive use, the potential harmful effects on aquatic organisms are of great concern. This study evaluated the effects of environmental concentrations of FLC and OTC on the genetic material of juvenile tilapia (Oreochromis niloticus) erythrocytes by using the comet assay and the occurrence of micronuclei (MN) and other erythrocytic nuclear abnormalities (ENAs) after exposure to 96 hour. The comet assay showed that fish erythrocytes exhibited significantly higher DNA damage after exposure to environmental concentrations of FLC and OTC. Although MN was not observed, ENAs were significantly higher after exposure to FLC, indicating that ENAs are a better biomarker for FLC than MN. The results showed that environmental concentrations of FLC and OTC were genotoxic to erythrocytes of O. niloticus; however, future studies on DNA damage recovery are needed. (C) 2015 Elsevier Ltd. All rights reserved.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionNational Council for Scientific and Technological Development
dc.descriptionUniv Sao Paulo, Ctr Energia Nucl Agr, Lab Ecotoxicol Aquat, BR-13416000 Piracicaba, SP, Brazil
dc.descriptionFHO UNIARARAS, Ctr Univ Herminio Ometto, BR-13607339 Sao Paulo, Brazil
dc.descriptionUniv Estadual Paraiba, UEPB, Ctr Ciencias Tecnol, Dept Estat, BR-58101001 Campina Grande, Paraiba, Brazil
dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho, Avenida 24 A, 1515, Rio Claro, São Paulo 13506-900, Brazil
dc.descriptionFAPESP: 2013/08143-5
dc.descriptionNational Council for Scientific and Technological Development: 456720/2014-6
dc.format206-212
dc.languageeng
dc.publisherElsevier B.V.
dc.relationChemosphere
dc.relation4.427
dc.relation1,435
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAntibiotic
dc.subjectComet assay
dc.subjectFishes
dc.subjectMicronuclei
dc.subjectNuclear abnormalities
dc.titleGenotoxic responses of juvenile tilapia (Oreochromis niloticus) exposed to florfenicol and oxytetracycline
dc.typeArtigo


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