Artigo
Ribifolin, an orbitide from jatropha ribifolia, and its potential antimalarial activity
Registro en:
Journal Of Natural Products. Washington: Amer Chemical Soc, v. 78, n. 3, p. 374-380, 2015.
0163-3864
10.1021/np5007668
WOS:000352033900006
9424346762460416
4484083685251673
0000-0002-4767-0904
Autor
Pinto, Meri Emili F. [UNESP]
Batista, Joao M. [UNESP]
Koehbach, Johannes
Gaur, Pratibha
Sharma, Abhinay
Nakabashi, Myna
Cilli, Eduardo Maffud [UNESP]
Giesel, Guilherme M.
Verli, Hugo
Gruber, Christian W.
Blanch, Ewan W.
Tavares, Joseam F.
Silva, Marcelo S. da
Garcia, Celia R. S.
Bolzani, Vanderlan da Silva [UNESP]
Resumen
A new orbitide named ribifolin was isolated and characterized from Jatropha ribifolia using mass spectrometry, NMR spectroscopy, quantitative amino acid analysis, molecular dynamics/simulated annealing, and Raman optical activity measurements and calculations. Ribifolin (1) and its linear form (1a) were synthesized by solid-phase peptide synthesis, followed by evaluation of its antiplasmodial and cytotoxicity activities. Compound 1 was moderately effective (IC50 = 42 mu M) against the Plasmodium falciparum strain 3D7. Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Universidade Estadual Paulista (UNESP), Instituto de Química (IQ), BR-14800060 Araraquara, SP, Brasil Univ Manchester, Manchester Inst Biotechnol, Manchester M1 7DN, Lancs, England Univ Manchester, Fac Life Sci, Manchester M1 7DN, Lancs, England Univ Queensland, Sch Biomed Sci, St Lucia, Qld 4072, Australia Med Univ Vienna, Ctr Physiol &Pharmacol, A-1090 Vienna, Austria Universidade de São Paulo (USP), Instituto de Biociências (IB), Departamento de Fisiologia, BR-05508900 São Paulo, Brasil Universidade Federal do Rio Grande do Sul (UFRGS), Ctr Biotechnol, BR-91500970 Porto Alegre, RS, Brasil Universidade Federal da Paraíba (UFPB), Lab Pharmaceut Technol, BR-58051970 João Pessoa, PB, Brasil Universidade Estadual Paulista (UNESP), Instituto de Química (IQ), BR-14800060 Araraquara, SP, Brasil FAPESP: 2010/52327-5 FAPESP: 2013/07600-3 CAPES: BEX: 9875/11-5 FAPESP: 2011/22339-4 FAPESP: 2012/13739-1