Artigo
Influence of beta-cyclodextrin on the properties of norfloxacin form A
Registro en:
Aaps Pharmscitech. New York: Springer, v. 16, n. 3, p. 683-691, 2015.
1530-9932
10.1208/s12249-014-0259-8
WOS:000357567600021
Autor
Chierentin, Lucas [UNESP]
Garnero, Claudia
Chattah, Ana Karina
Delvadia, Poonam
Karnes, Thomas
Longhi, Marcela Raquel
Salgado, Herida Regina Nunes [UNESP]
Resumen
Cyclodextrins are able to form host-guest complexes with hydrophobic molecules to result in the formation of inclusion complexes. The complex formation between norfloxacin form A and beta-cyclodextrin was studied by exploring its structure affinity relationship in an aqueous solution and in the solid state. Kneading, freeze-drying, and physical mixture methods were employed to prepare solid complexes of norfloxacin and beta-cyclodextrin. The solubility of norfloxacin significantly increased upon complexation with beta-cyclodextrin as demonstrated by a solubility isotherm of the AL type along with the results of an intrinsic dissolution study. The complexes were also characterized in the solid stated by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Fourier-transform infrared (FT-IR) spectroscopy, X-ray diffractometry, scanning electron microscopy (SEM), and solid-state nuclear magnetic resonance (ssNMR) spectrometry. The thermal analysis showed that the thermal stability of the drug is enhanced in the presence of beta-cyclodextrin. Finally, the microbiological studies showed that the complexes have better potency when compared with pure drug. Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET) Secretaria de Ciencia y Tecnica de la Universidad Nacional de Cordoba (SECyT-UNC) Ministerio de Ciencia y Tecnologia (MinCyT) de la Provincia de Cordoba Universidad Nacional Cordoba, Departamento de Farmacia, Faculdad Ciencias Químicas Universidad Nacional Cordoba, Facultad de Matemática, Astronomía y Física Virginia Commonwealth University, Department of Pharmaceutics, School of Pharmacy Universidade Estadual Paulista, Departamento de Fármacos e Medicamentos, Faculdade de Ciências Farmacêuticas de Araraquara FAPESP: 2010/13335-2