Artigo
Ruthenium(II) complexes with hydroxypyridinecarboxylates: screening potential metallodrugs against Mycobacterium tuberculosis
Registro en:
Polyhedron. Oxford: Pergamon-elsevier Science Ltd, v. 85, p. 376-382, 2015.
0277-5387
10.1016/j.poly.2014.08.057
WOS:000347582900047
Autor
Barbosa, Marilia I. F.
Correa, Rodrigo S.
Pozzi, Lucas V.
Lopes, Erica de O. [UNESP]
Pavan, Fernando R. [UNESP]
Leite, Clarice Q. F. [UNESP]
Ellena, Javier
Machado, Sergio de P.
Von Poelhsitz, Gustavo
Batista, Alzir A.
Resumen
Three promising antimycobacterium tuberculosis ruthenium(II) complexes with the deprotonated ligands 2-hydroxynicotinic acid (2-OHnicH), 6-hydroxynicotinic acid (6-OHnicH) and 3-hydroxypicolinic acid (3-OHpicH) were synthesized and characterized. Structural analysis revealed three different coordination modes depending of the hydroxypyridinecarboxylate ligand. In the complex [Ru(2-OHnic)(dppb)(bipy)PF6 (1), the 2-OHnic anion is coordinated by the O,O-chelating mode (via carboxylate group and phenolate oxygen), in the Ru(6-OHnic)(dppb)(bipy)]PF6 (2) a O-O chelation by the carboxylate group is observed for the 6-OHnic ligand and for the complex [Ru(3-OHpic)(dppb)(bipy))PF6 (3) a N,O-chelating mode (via carboxylate) occurs to the 3-OHpic anion. The compounds were evaluated for activity against Mycobacterium tuberculosis H(37)Rv ATCC 27294 using Resazurin Microtitre Assay (REMA) plate method and cytotoxicity in VERO CCL-81 cell line. All the synthesized compounds exhibited good antimycobacterial activity and a completely lack of cytotoxicity activity, indicating a good selectivity index. (C) 2014 Elsevier Ltd. All rights reserved. Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG) Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP, Brazil Univ Estadual Paulista, Dept Ciencias Biol, Fac Ciencias Farmaceut, BR-14800900 Araraquara, SP, Brazil Univ Sao Paulo, Inst Fis Sao Carlos, BR-13560970 Sao Carlos, SP, Brazil Univ Fed Rio de Janeiro, Inst Quim, BR-21941590 Rio De Janeiro, RJ, Brazil Univ Fed Uberlandia, Inst Quim, BR-38400902 Uberlandia, MG, Brazil Departamento de Ciências Biológicas, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista, CEP: 14800-900, Araraquara (SP) Brazil FAPESP: 2013/26559-4