Artigo
A flexible lab-on-a-chip for the synthesis and magnetic separation of magnetite decorated with gold nanoparticles
Registro en:
Lab On A Chip, v. 15, n. 8, p. 1835-1841, 2015.
1473-0197
10.1039/c4lc01483a
WOS:000352088400005
Autor
Cabrera, Flavio C. [UNESP]
Melo, Antonio F. A. A.
Souza, Joao C. P. de
Job, Aldo E. [UNESP]
Crespilho, Frank N.
Resumen
Magnetite decorated with gold nanoparticles (Fe3O4-AuNPs) is a ferrimagnetic material with unprecedented applications in immunosensors, as a contrast agent for imaging diagnosis, and for the photothermal ablation of tumor cells. Here, we show the preparation of controlled amounts of Fe3O4-AuNPs without organic solvents, surfactants, or heat treatment. For this, we have developed a customized natural-rubber-based microfluidic device (NRMD) as a flexible lab-on-a-chip for the decoration of Fe3O4 with AuNPs. With a novel NRMD configuration, monodisperse Fe3O4-NPs (phi = 10 nm) decorated with AuNPs (phi = 4 nm) were readily obtained. The AuNPs were homogenous in terms of their size and their distribution on the Fe3O4-NP surfaces. Furthermore, the lab-on-a-chip was projected with an internal system for magnetic separation, an innovation in terms of aqueous/carrier phase separation. Finally, the nanomaterials produced with this NRMD are free of organic solvents and surfactants, allowing them to be used directly for medical applications. Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Brazilian agency INEO Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) UNESP, FCT, Dept Fis Quim &Biol, Presidente Prudente, SP, Brazil Univ Sao Paulo, Inst Quim, Sao Carlos, SP, Brazil UNESP, FCT, Dept Fis Quim &Biol, Presidente Prudente, SP, Brazil FAPESP: 2013/14262-7 FAPESP: 2013/04663-4 CNPq: 306106/2013-2 CNPq: 478525/2013-3 FAPESP: 2011/23362-0