Resenha
Prevalence of Treponema Species Detected in Endodontic Infections: Systematic Review and Meta-regression Analysis
Registro en:
Journal Of Endodontics. New York: Elsevier Science Inc, v. 41, n. 5, p. 579-587, 2015.
0099-2399
10.1016/j.joen.2015.01.020
WOS:000354597200002
1754020652874850
0000-0003-4830-0400
Autor
Leite, Fabio R. M.
Nascimento, Gustavo G.
Demarco, Flavio F.
Gomes, Brenda P. F. A.
Pucci, Cesar R. [UNESP]
Martinho, Frederico C. [UNESP]
Resumen
Introduction: This systematic review and meta-regression analysis aimed to calculate a combined prevalence estimate and evaluate the prevalence of different Treponema species in primary and secondary endodontic infections, including symptomatic and asymptomatic eases. Methods: The MEDLINE/PubMed, Embase, Scielo, Web of Knowledge, and Scopus data-bases were searched without starting date restriction up to and including March 2014. Only reports in English were included. The selected literature was reviewed by 2 authors and classified as suitable or not to be included in this review. Lists were compared, and, in case of disagreements, decisions were made after a discussion based on inclusion and exclusion criteria. A pooled prevalence of Treponema species in endodontic infections was estimated. Additionally, a meta-regression analysis was performed. Results: Among the 265 articles identified in the initial search, only 51 were included in the final analysis. The studies were classified into 2 different groups according to the type of endodontic infection and whether it was an exclusively primary/secondary study (n = 36) or a primary/secondary comparison (n = 15). The pooled prevalence of Treponema species was 41.5% (95% confidence interval, 35.9-47.0). In the multivariate model of meta-regression analysis, primary endodontic infections (P < .001), acute apical abscess, symptomatic apical periodontitis (P < .001), and concomitant presence of 2 or more species (P = .028) explained the heterogeneity regarding the prevalence rates of Treponema species. Conclusions: Our findings suggest that Treponema species are important pathogens involved in endodontic infections, particularly in cases of primary and acute infections. Univ Fed Pelotas, Sch Dent, UFPel, Postgrad Program Dent,Dept Semiol &Clin, Pelotas, RS, Brazil Univ Fed Pelotas, Sch Dent, UFPel, Postgrad Program Dent,Dept Restorat Dent, Pelotas, RS, Brazil Univ Estadual Campinas, UNICAMP, Piracicaba Dent Sch, Dept Restorat Dent,Endodont Div, Piracicaba, SP, Brazil State Univ Sao Paulo, UNESP, Dept Restorat Dent, Dent Sch,Endodont Div, BR-12245000 Sao Paulo, Brazil State Univ Sao Paulo, UNESP, Dept Restorat Dent, Dent Sch,Endodont Div, BR-12245000 Sao Paulo, Brazil