Microorganisms in the female genital tract during pregnancy: tolerance versus pathogenesis

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorWeill Cornell Medical College
dc.creatorRamos, Bruna de Andrade [UNESP]
dc.creatorKanninen, Tomi T.
dc.creatorSisti, Giovanni
dc.creatorWitkin, Steven S.
dc.date2015-10-21T13:09:24Z
dc.date2015-10-21T13:09:24Z
dc.date2015-05-01
dc.date.accessioned2023-09-12T06:33:28Z
dc.date.available2023-09-12T06:33:28Z
dc.identifierhttp://onlinelibrary.wiley.com/doi/10.1111/aji.12326/abstract;jsessionid=B25B9BCD0184A396C7A7DAD0355E1EB8.f02t03
dc.identifierAmerican Journal Of Reproductive Immunology. Hoboken: Wiley-blackwell, v. 73, n. 5, p. 383-389, 2015.
dc.identifier1046-7408
dc.identifierhttp://hdl.handle.net/11449/128377
dc.identifier10.1111/aji.12326
dc.identifierWOS:000352810200001
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8777728
dc.descriptionMicroorganisms in the pregnant female genital tract are not always associated with pathology. The factors that influence the maternal response to microorganisms remain ill defined. We review the state of knowledge of microbe-host interactions in gestational tissues and highlight mechanisms that promote tolerance or pathogenesis. Tolerance to microorganisms is promoted during pregnancy by several mechanisms including upregulation of anti-inflammatory mediators, induction of endotoxin tolerance, and possibly by regulation of autophagy. Conversely, an altered vaginal microbiota or a pre-existing viral presence may result in induction of excessive inflammation and preterm labor. Although infections play a prevalent role in preterm birth, microbes are present in gestational tissues of women with healthy outcomes and may provide beneficial functions. The complex interactions between different microbial species and the maternal immune system during gestation remain incompletely elucidated.
dc.descriptionWeill Cornell Medical College, Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology
dc.descriptionUniversidade Estadual Paulista, Departamento de Patologia, Faculdade de Medicina de Botucatu
dc.format383-389
dc.languageeng
dc.publisherWiley-Blackwell
dc.relationAmerican Journal Of Reproductive Immunology
dc.relation2.745
dc.relation1,210
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAutophagy
dc.subjectImmune tolerance
dc.subjectMicrobial colonization
dc.subjectMicrobial infection
dc.subjectPreterm birth
dc.titleMicroorganisms in the female genital tract during pregnancy: tolerance versus pathogenesis
dc.typeResenha


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