Increasing Doxycycline Hyclate Photostability by Complexation with beta-Cyclodextrin

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniv Nacl Cordoba
dc.creatorKogawa, Ana Carolina [UNESP]
dc.creatorZoppi, Ariana
dc.creatorAlfredo Quevedo, Mario
dc.creatorSalgado, Hérida Regina Nunes [UNESP]
dc.creatorRaquel Longhi, Marcela
dc.date2015-03-18T15:55:53Z
dc.date2015-03-18T15:55:53Z
dc.date2014-10-01
dc.date.accessioned2023-09-12T03:10:30Z
dc.date.available2023-09-12T03:10:30Z
dc.identifierhttp://dx.doi.org/10.1208/s12249-014-0150-7
dc.identifierAaps Pharmscitech. New York: Springer, v. 15, n. 5, p. 1209-1217, 2014.
dc.identifier1530-9932
dc.identifierhttp://hdl.handle.net/11449/117342
dc.identifier10.1208/s12249-014-0150-7
dc.identifierWOS:000342489200018
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8766826
dc.descriptionDoxycycline hyclate (DOX) is a highly photosensitive drug, a feature that limits the stability of the corresponding dosage forms. The main objectives of this work were the preparation and characterization of an inclusion complex of DOX with beta-cyclodextrin (beta CD) and to investigate if this approach could improve the photostability of the drug. Guest-host interactions were investigated using nuclear magnetic resonance, which were afterwards combined with molecular modeling methods to study the complex formation and its three-dimensional structure was proposed. A freeze-drying method was applied to obtain the complex in the solid state, which was further confirmed by thermal and spectroscopic techniques. To evaluate the complexation effect on DOX integrity, the photostability of the inclusion complex was studied, with a significant decrease in the photodegradation of DOX being found in aqueous solution upon complexation. Finally, the photoprotection produced by the complexation was evaluated by means of an antimicrobial assay. Overall, the presented results suggest that the formulation of DOX complexed with beta CD constitutes an interesting approach for the preparation of pharmaceutical dosage forms of DOX with enhanced stability properties.
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionPADC-FCF
dc.descriptionFundação para o Desenvolvimento da UNESP (FUNDUNESP)
dc.descriptionSecretaria de Ciencia y Tecnica de la Universidad Nacional de Cordoba (SECyT)
dc.descriptionConsejo Nacional de Investigaciones Cientificas y Tecnologicas de la Nacion Argentina (CONICET)
dc.descriptionUniv Estadual Paulista, Fac Ciencias Farmaceut, Dept Farmacos & Medicamentos, Sao Paulo, Brazil
dc.descriptionUniv Nacl Cordoba, Unidad Invest & Desarrollo Tecnol Farmaceut UNITE, CONICET, RA-5000 Cordoba, Argentina
dc.descriptionUniv Nacl Cordoba, Dept Farm, Fac Ciencias Quim, RA-5000 Cordoba, Argentina
dc.descriptionUniv Estadual Paulista, Fac Ciencias Farmaceut, Dept Farmacos & Medicamentos, Sao Paulo, Brazil
dc.format1209-1217
dc.languageeng
dc.publisherSpringer
dc.relationAaps Pharmscitech
dc.relation2.666
dc.relation0,752
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectbeta-cyclodextrin
dc.subjectdoxycycline hyclate
dc.subjectmicrobiological assay
dc.subjectmolecular modeling
dc.subjectphotostability
dc.titleIncreasing Doxycycline Hyclate Photostability by Complexation with beta-Cyclodextrin
dc.typeArtigo


Este ítem pertenece a la siguiente institución