Artigo
Determinants of baseline seroreactivity to human papillomavirus type 16 in the Ludwig-McGill cohort study
Registro en:
Bmc Infectious Diseases. London: Biomed Central Ltd, v. 14, 9 p., 2014.
1471-2334
10.1186/s12879-014-0578-0
WOS:000345710200001
WOS000345710200001.pdf
0000-0003-1515-702X
Autor
Araujo-Souza, Patricia S. de
Ramanakumar, Agnihotram V.
Candeias, Joao M. G. [UNESP]
Thomann, Patricia
Trevisan, Andrea
Franco, Eduardo L.
Villa, Luisa L.
Resumen
Background: Immunity plays an important role in controlling human papillomavirus (HPV) infection and associated lesions. Unlike infections caused by other viruses, natural HPV infection does not always result in a protective antibody response. Therefore, HPV antibodies are also considered markers of cumulative exposure. The aim of this study was to identify determinants of HPV16 seroreactivity at enrollment among women from the Ludwig-McGill cohort, a natural history study of HPV infection and risk of cervical neoplasia.Methods: HPV16 serology was assessed by ELISA for L1 and L2 capsid antigens, while HPV typing and viral load measurements were performed by PCR-based methods. The associations were analyzed by unconditional logistic regression.Results: Of 2049 subjects, 425 (20.7%) were strongly seropositive for HPV16. In multivariate analysis, seroreactivity was positively correlated with age, lifetime number of sexual partners, frequency of sex, and HPV16 viral load, and negatively associated with duration of smoking.Conclusions: HPV16 seroreactivity is determined by factors that reflect viral exposure. Ludwig Institute for Cancer Research U.S. National Cancer Institute Canadian Institutes of Health Research Ludwig Inst Canc Res, Sao Paulo, Brazil Univ Fed Fluminense, Dept Immunobiol, Niteroi, RJ, Brazil Brazilian Natl Canc Inst, Program Cellular Biol, Rio De Janeiro, Brazil McGill Univ, Dept Oncol, Montreal, PQ, Canada Univ Estadual Paulista, Inst Biosci, Dept Microbiol & Immunol, Botucatu, SP, Brazil Inst Gynaecol Canc Res, Sao Paulo, Brazil Univ Montreal, CHUM, Div Gynecol Oncol, Montreal, PQ, Canada McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada ICESP, Sao Paulo Canc Inst, Mol Biol Lab, Sao Paulo, Brazil Univ Sao Paulo, Sch Med, Dept Radiol & Oncol, Sao Paulo, Brazil Univ Sao Paulo, Sch Med, Sao Paulo, Brazil Santa Casa Sao Paulo, Sao Paulo, Brazil Univ Estadual Paulista, Inst Biosci, Dept Microbiol & Immunol, Botucatu, SP, Brazil U.S. National Cancer InstituteCA70269 Canadian Institutes of Health Research49396 Canadian Institutes of Health Research83320