Nanotechnological Strategies for Vaginal Administration of Drugs-A Review

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.creatorSilva, Patricia Bento da [UNESP]
dc.creatorSantos Ramos, Matheus Aparecido dos [UNESP]
dc.creatorBonifacio, Bruna Vidal [UNESP]
dc.creatorSilveira Negri, Kamila Maria [UNESP]
dc.creatorSato, Mariana Rillo [UNESP]
dc.creatorBauab, Taís Maria [UNESP]
dc.creatorChorilli, Marlus [UNESP]
dc.date2015-03-18T15:55:43Z
dc.date2015-03-18T15:55:43Z
dc.date2014-09-01
dc.date.accessioned2023-09-12T03:09:31Z
dc.date.available2023-09-12T03:09:31Z
dc.identifierhttp://dx.doi.org/10.1166/jbn.2014.1890
dc.identifierJournal Of Biomedical Nanotechnology. Valencia: Amer Scientific Publishers, v. 10, n. 9, p. 2218-2243, 2014.
dc.identifier1550-7033
dc.identifierhttp://hdl.handle.net/11449/117285
dc.identifier10.1166/jbn.2014.1890
dc.identifierWOS:000339430600023
dc.identifier4910754838277580
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8766770
dc.descriptionWomen frequently develop disorders related to the vaginal area, including problems with the immune system, hygiene, genetic aspects and sexually transmitted diseases. Compared with other mucosal application sites, the vagina represents local effect as well as systemic drug delivery and is able to avoid the first-pass effect due to its large surface area, high blood supply and permeability to many active ingredients. It has been widely proposed that the use of drugs to treat vaginal disorders be combined with nanotechnology because nanosystems often potentiate the action of most active constituents, reducing the required dosage and side effects and improving the resulting activity in comparison with conventional treatments. Following the trend of using drug delivery systems based on nanotechology, many studies have encouraged the scientific community to turn to the development of new strategies for the vaginal administration of drugs. This study proposes to review the most common nanotechnology-based drug delivery systems that have been used to improve the effectiveness of active compounds administrated to treat vaginal disorders.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionPADC/FCF-UNESP (Araraquara, Brazil)
dc.descriptionSao Paulo State Univ, Postgrad Program Pharmaceut Sci, Sch Pharmaceut, Dept Drugs & Med, BR-14801902 Sao Paulo, SP, Brazil
dc.descriptionSao Paulo State Univ, Postgrad Program Pharmaceut Sci, Sch Pharmaceut, Dept Biol Sci, BR-14801902 Sao Paulo, SP, Brazil
dc.descriptionSao Paulo State Univ, Postgrad Program Pharmaceut Sci, Sch Pharmaceut, Dept Drugs & Med, BR-14801902 Sao Paulo, SP, Brazil
dc.descriptionSao Paulo State Univ, Postgrad Program Pharmaceut Sci, Sch Pharmaceut, Dept Biol Sci, BR-14801902 Sao Paulo, SP, Brazil
dc.format2218-2243
dc.languageeng
dc.publisherAmer Scientific Publishers
dc.relationJournal Of Biomedical Nanotechnology
dc.relation5.068
dc.relation0,828
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectNanotechnology
dc.subjectVaginal Disorders
dc.subjectDrug Delivery Systems
dc.subjectVaginal Administration
dc.subjectNanoformulations
dc.titleNanotechnological Strategies for Vaginal Administration of Drugs-A Review
dc.typeArtigo


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