Artigo
Association between interleukin-6 polymorphism in the-174 G/C region and hearing loss in the elderly with a history of occupational noise exposure
Registro en:
Brazilian Journal Of Otorhinolaryngology. Sao Paulo: Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial, v. 80, n. 5, p. 373-378, 2014.
1808-8694
10.1016/j.bjorl.2014.07.001
WOS:000344136700003
WOS000344136700003.pdf
Autor
Braga, Miula Portelinha
Maciel, Sandra Mara
Moraes Marchiori, Luciana Lozza de
Poli-Frederico, Regina Celia [UNESP]
Resumen
Introduction: The biological processes involved in noise-induced hearing loss (NIHL) are still unclear. The involvement of inflammation in this condition has been suggested.Objective: To investigate the association between interleukin - 6 (IL-6) polymorphism and susceptibility to NIHL.Methods: This was a cross-sectional study with a sample of 191 independent elderly individuals aged >60 years of age. Information on exposure to occupational noise was obtained by interviews. Audiological evaluation was performed using pure tone audiometry and genotyped through PCR by restriction fragment length polymorphism - PCR-RFLP. Data were analyzed using the chi-square test and the odds ratio (OR), with the significance level set at 5%.Results: Among elderly with hearing loss (78.0%), 18.8% had a history of exposure to occupational noise. There was a statistically significant association between the genotype frequencies of the IL-6 - 174 and NIHL. The elderly with the CC genotype were less likely to have hearing loss due to occupational noise exposure when compared to those carrying the GG genotype (OR = 0.0124; 95% CI 0.0023-0.0671; p<0.001).Conclusion: This study suggests there is an association of polymorphisms in the IL-6 gene at position - G174C with susceptibility to noise-induced hearing loss. (C) 2014 Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial. Published by Elsevier Editora Ltda. All rights reserved. FUNADESP / Brazil (Fundacao Nacional de Desenvolvimento do Ensino Superior Particular) Univ Norte Parana UNOPAR, Londrina, PR, Brazil Univ London, London, England Univ Estadual Maringa, Dept Pediat Dent, Maringa, Parana, Brazil Univ Estadual Londrina, Londrina, PR, Brazil Univ Estadual Paulista Julio Mesquita Filho UNESP, Botucatu, PR, Brazil Univ Estadual Paulista Julio Mesquita Filho UNESP, Botucatu, PR, Brazil