Artigo
Bone Morphogenetic Proteins: Structure, biological function and therapeutic applications
Registro en:
Archives Of Biochemistry And Biophysics. New York: Elsevier Science Inc, v. 561, p. 64-73, 2014.
0003-9861
10.1016/j.abb.2014.07.011
WOS:000342863300009
Autor
Carreira, Ana Claudia
Alves, Gutemberg Gomes
Zambuzzi, William Fernando [UNESP]
Sogayar, Mari Cleide
Granjeiro, Jose Mauro
Resumen
Bone Morphogenetic Proteins (BMPs) are multifunctional secreted cytokines, which belong to the TGF-beta superfamily. These glycoproteins act as a disulfide-linked homo- or heterodimers, being potent regulators of bone and cartilage formation and repair, cell proliferation during embryonic development and bone homeostasis in the adult. BMPs are promising molecules for tissue engineering and bone therapy. The present review discusses this family of proteins, their structure and biological function, their therapeutic applications and drawbacks, their effects on mesenchymal stem cells differentiation, and the cell signaling pathways involved in this process. (C) 2014 Published by Elsevier Inc. Brazilian Federal agency Sao Paulo State research agency Univ Sao Paulo, Dept Biochem, Inst Chem, BR-05508000 Sao Paulo, Brazil Univ Sao Paulo, Sch Med, Dept Clin Med, NUCEL NETCEM Cell & Mol Therapy Ctr, BR-05508000 Sao Paulo, Brazil Univ Fed Fluminense, Inst Biol, Dept Cell & Mol Biol, Niteroi, RJ, Brazil Univ Estadual Paulista, UNESP, Biosci Inst, Dept Chem & Biochem, Botucatu, SP, Brazil Natl Inst Metrol Qual & Technol, Bioengn Div, Duque De Caxias, RJ, Brazil Univ Fed Fluminense, Sch Dent, Dept Dent Mat, Niteroi, RJ, Brazil Univ Estadual Paulista, UNESP, Biosci Inst, Dept Chem & Biochem, Botucatu, SP, Brazil