Artigo
Bioaccumulation of butyltins and liver damage in the demersal fish Cathorops spixii (Siluriformes, Ariidae)
Registro en:
Environmental Science And Pollution Research. Heidelberg: Springer Heidelberg, v. 21, n. 4, p. 3166-3174, 2014.
0944-1344
10.1007/s11356-013-2280-y
WOS:000331815100070
Autor
Santos, Dayana Moscardi dos [UNESP]
Santos, Gustavo Souza
Cestari, Marta Margarete
Oliveira Ribeiro, Ciro Alberto de
Silva de Assis, Helena Cristina
Yamamoto, Flavia
Guiloski, Izonete Cristina
Rodrigues de Marchi, Mary Rosa [UNESP]
Montone, Rosalinda Carmela
Resumen
The toxicity of butyltin compounds (BTs), mainly tributyltin (TBT), has been reported in different organisms. However, such an analysis in fish after field exposure with reference to the related biomarkers has not been commonly observed in the literature. This study presents the uptake of BTs in the liver of a neotropical marine catfish Cathorops spixii in Paranagua Bay, an important estuarine system located in southern Brazil. Two different areas, close to and distant from the harbor, were used for chemical analysis evaluation of hepatotoxicity through genetic, enzymatic, and histopathological biomarkers. The presence of polycyclic aromatic hydrocarbons in bile was also considered as a biomarker. The results showed a significant relationship between TBT levels and the inhibition of biotransformation enzymes and high occurrence of melanomacrophages in fish collected close to the harbor site. These effects were linked to the absence of TBT metabolites in the liver. In the second site, the presence of DBT was associated with an increase in EROD and GST activity. The larger amount of DNA damage as well as the highest oxidative stress was noted in fish from the less TBT-polluted area, where DBT and bile PAHs occurred. These findings showed different impact levels due to or increased by the chronic exposure of biota to BTs. Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) FACTE Univ Sao Paulo, Oceanog Inst, Dept Phys Chem & Geol Oceanog, Sao Paulo, Brazil Univ Estadual Paulista, UNESP, Inst Chem, Dept Analyt Chem, BR-14800900 Sao Paulo, Brazil Univ Fed Parana, Dept Genet, BR-80060000 Curitiba, Parana, Brazil Univ Fed Parana, Dept Cell Biol, BR-80060000 Curitiba, Parana, Brazil Univ Fed Parana, Dept Pharmacol, BR-80060000 Curitiba, Parana, Brazil Univ Estadual Paulista, UNESP, Inst Chem, Dept Analyt Chem, BR-14800900 Sao Paulo, Brazil