Production of the First Effective Hyperimmune Equine Serum Antivenom against Africanized Bees

dc.contributorUniversidade de São Paulo (USP)
dc.contributorInst Invest Immunol INCT
dc.contributorInstituto Butantan
dc.contributorUniv Sao Francisco
dc.contributorInst Technol Parana
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.creatorSantos, Keity Souza
dc.creatorStephano, Marco Antonio
dc.creatorMarcelino, Jose Roberto
dc.creatorResende Ferreira, Virginia Maria
dc.creatorRocha, Thalita
dc.creatorCaricati, Celso
dc.creatorHigashi, Hisako Gondo
dc.creatorMoro, Ana Maria
dc.creatorKalil, Jorge Elias
dc.creatorMalaspina, Osmar [UNESP]
dc.creatorMorato Castro, Fabio Fernandes
dc.creatorPalma, Mario Sergio [UNESP]
dc.date2014-12-03T13:11:00Z
dc.date2014-12-03T13:11:00Z
dc.date2013-11-13
dc.date.accessioned2023-09-09T10:03:28Z
dc.date.available2023-09-09T10:03:28Z
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0079971
dc.identifierPlos One. San Francisco: Public Library Science, v. 8, n. 11, 10 p., 2013.
dc.identifier1932-6203
dc.identifierhttp://hdl.handle.net/11449/112708
dc.identifier10.1371/journal.pone.0079971
dc.identifierWOS:000327254700167
dc.identifierWOS000327254700167.pdf
dc.identifier7538556085505819
dc.identifier2901888624506535
dc.identifier0000-0002-1650-257X
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8762329
dc.descriptionVictims of massive bee attacks become extremely ill, presenting symptoms ranging from dizziness and headache to acute renal failure and multiple organ failure that can lead to death. Previous attempts to develop specific antivenom to treat these victims have been unsuccessful. We herein report a F(ab)'(2)-based antivenom raised in horse as a potential new treatment for victims of multiple bee stings. The final product contains high specific IgG titers and is effective in neutralizing toxic effects, such as hemolysis, cytotoxicity and myotoxicity. The assessment of neutralization was revised and hemolysis, the primary toxic effect of these stings, was fully neutralized in vivo for the first time.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFINEP (CT-BIOTEC-Anticorpos -MCTFINEP)
dc.descriptionButantan Institute
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionUniv Sao Paulo, Sch Med, FMUSP, Div Clin Immunol & Allergy, Sao Paulo, Brazil
dc.descriptionInst Invest Immunol INCT, Sao Paulo, Brazil
dc.descriptionUniv Sao Paulo, Fac Ciencias Farmaceut, Sao Paulo, Brazil
dc.descriptionButantan Inst, Div Hyperimmune Plasmas, Sao Paulo, Brazil
dc.descriptionUniv Sao Francisco, Sch Med, BR-12900000 Braganca Paulista, SP, Brazil
dc.descriptionButantan Inst, Special Pilot Lab Res & Dev Vet Immunobiol, Sao Paulo, Brazil
dc.descriptionInst Technol Parana, Curitiba, Parana, Brazil
dc.descriptionButantan Inst, Lab Biopharmaceut Anim Cells, Sao Paulo, Brazil
dc.descriptionUniv Sao Paulo, Sch Med, Heart Inst InCor, LIM 19, Sao Paulo, Brazil
dc.descriptionUniv Sao Paulo State UNESP, Ctr Study Social Insects, Inst Biosci, Dept Biol, Rio Claro, SP, Brazil
dc.descriptionUniv Sao Paulo State UNESP, Ctr Study Social Insects, Inst Biosci, Dept Biol, Rio Claro, SP, Brazil
dc.descriptionFAPESP: 11/51684-1
dc.format10
dc.languageeng
dc.publisherPublic Library Science
dc.relationPLOS ONE
dc.relation2.766
dc.relation1,164
dc.rightsAcesso aberto
dc.sourceWeb of Science
dc.titleProduction of the First Effective Hyperimmune Equine Serum Antivenom against Africanized Bees
dc.typeArtigo


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