Artigo
Allele frequency of hereditary equine regional dermal asthenia in American Quarter horses in Brazil determined by quantitative real-time PCR with high resolution melting analysis
Registro en:
Veterinary Journal. Oxford: Elsevier Sci Ltd, v. 199, n. 2, p. 306-307, 2014.
1090-0233
10.1016/j.tvjl.2013.11.008
WOS:000331918700022
9643433706163946
Autor
Badial, Peres R. [UNESP]
Oliveira-Filho, Jose P. [UNESP]
Winand, Nena J.
Borges, Alexandre Secorun [UNESP]
Resumen
Hereditary equine regional dermal asthenia (HERDA) is a genetic disorder that occurs in the American Quarter horse (AQH) and is caused by a c.115G>A missense mutation in the peptidylprolyl isomerase B (PPIB) gene. Using a quantitative real-time PCR high resolution melting analysis genotyping assay for the PPIB mutation, the estimated HERDA allele and carrier frequencies in a sample of Brazilian AQHs were 2.9% and 5.8%, respectively. (C) 2013 Elsevier Ltd. All rights reserved. Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Univ Estadual Paulista, Sch Vet Med & Anim Sci, Dept Vet Clin Sci, Sao Paulo, Brazil Cornell Univ, Coll Vet Med, Dept Mol Med, Ithaca, NY 14853 USA Univ Estadual Paulista, Sch Vet Med & Anim Sci, Dept Vet Clin Sci, Sao Paulo, Brazil FAPESP: 09/17764-8 FAPESP: 10/08774-7