Reconstruction of molecular networks involved in citokine-induced myotubes atrophy integrating microRNA and mRNA expression

dc.contributorPai, Maeli Dal [UNESP]
dc.contributorCarvalho, Robson Francisco [UNESP]
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.creatorFernandez Garcia, Geysson Javier [UNESP]
dc.date2014-08-13T14:50:45Z
dc.date2014-08-13T14:50:45Z
dc.date2013-09-26
dc.date2013
dc.date.accessioned2023-09-09T08:55:17Z
dc.date.available2023-09-09T08:55:17Z
dc.identifierFERNANDEZ GARCIA, Geysson Javier. Reconstruction of molecular networks involved in citokine-induced myotubes atrophy integrating microRNA and mRNA expression. 2013. 93 f. Dissertação (mestrado) - Universidade Estadual Paulista Julio de Mesquita Filho, Instituto de Biociências de Botucatu, 2013.
dc.identifierhttp://hdl.handle.net/11449/108576
dc.identifier000755543
dc.identifier000755543.pdf
dc.identifier33004064026P9
dc.identifier5406518799128485
dc.identifier6171323341671821
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8758395
dc.descriptionThe skeletal muscle atrophy is a common phenomenon in many chronic systemic diseases such a sepsis, chronic heart failure, chronic obstructive pulmonary disease, chronic kidney disease, diabetes, AIDS and cancer. These diseases may be accompanied by a complex metabolic syndrome characterized by muscle wasting, denominated cachexia. The molecular pathways responsible for cachexia are not completely understood, however, evidence suggest that pro-inflammatory cytokines like Tumor Necrosis Factor (TNF)-α and Interferon (INF)-γ have a key role in molecular pathways related to loss of function and muscle mass. The complexity of mechanisms controlling gene expression in this process suggests the involvement of additional regulatory molecules, such as microRNAs; these RNA molecules encoded by the genome regulate the function of skeletal muscle during development and various muscle diseases. MicroRNAs orchestrate common pathways or biological function, this unique feature gives rise as an effective tool for determining the pathways involved in specific diseases or biological processes. The hypothesis of this work is that the muscle atrophy induced by TNF-α and INF-γ has a microRNAs expression profile that allow the identification of regulatory networks and molecular pathways
dc.format93 f.
dc.languagepor
dc.publisherUniversidade Estadual Paulista (Unesp)
dc.rightsAcesso aberto
dc.rightsLOCKSS system has permission to collect, preserve, and serve this Archival Unit
dc.sourceAleph
dc.subjectAtrofia muscular
dc.subjectSistema musculoesquelético
dc.subjectSíndrome metabólica
dc.subjectCaquexia
dc.subjectMetabolic syndrome
dc.titleReconstruction of molecular networks involved in citokine-induced myotubes atrophy integrating microRNA and mRNA expression
dc.typeDissertação de mestrado


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