INJECTION OF RAMIPRIL INTO THE LATERAL VENTRICLE INTERFERES WITH THE DRINKING RESPONSE INDUCED BY PHARMACOLOGICAL AND NATURAL THIRST STIMULI

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorSaad, W. A.
dc.creatorLuiz, A. C.
dc.creatorCamargo, LAA
dc.creatorMenani, José Vanderlei
dc.creatorRenzi, Antonio
dc.creatorSilveira, JEN
dc.creatorPaulino, M. A.
dc.date2014-05-20T15:19:43Z
dc.date2016-10-25T17:52:37Z
dc.date2014-05-20T15:19:43Z
dc.date2016-10-25T17:52:37Z
dc.date1994-12-01
dc.date.accessioned2017-04-05T23:21:38Z
dc.date.available2017-04-05T23:21:38Z
dc.identifierBrazilian Journal of Medical and Biological Research. São Paulo: Associação Bras Divulg Cientifica, v. 27, n. 12, p. 2909-2913, 1994.
dc.identifier0100-879X
dc.identifierhttp://hdl.handle.net/11449/31115
dc.identifierhttp://acervodigital.unesp.br/handle/11449/31115
dc.identifierWOS:A1994PY70100021
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_issues&pid=0100-879X&lng=en&nrm=iso
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/875736
dc.descriptionWe investigated the effects of ramipril, an angiotensin I-converting enzyme (ACE) inhibitor, on water intake by male Holtzman rats (250-300 g) with cannulae implanted into the lateral ventricle. Intracerebroventricular (icv) injection of ramipril (1 mu g/mu l) significantly reduced drinking in response to subcutaneous (sc) injection of isoprenaline (100 mu g/kg) from 8.49 +/- 0.69 to 2.96 +/- 0.36 ml/2 h, polyethyleneglycol (PEG) (30% w/v, 10 ml/kg) from 9.51 +/- 2.20 to 1.6 +/- 0.34 ml/2 h or water deprivation for 24 h from 12.61 +/- 0.83 to 5.10 +/- 1.37 ml/2 h. Ramipril had no effect on water intake induced by cellular dehydration produced by sc injection of hypertonic saline (2 M NaCl). These results are consistent with the hypothesis that ramipril acts as an ACE-blocking agent in the brain. The possibility that ramipril is transformed to ramiprilat, the active drug, by the brain is suggested.
dc.languageeng
dc.publisherAssociação Brasileira de Divulgação Científica (ABRADIC)
dc.relationBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectRAMIPRIL
dc.subjectCENTRAL NERVOUS SYSTEM
dc.subjectANGIOTENSIN
dc.subjectWATER INTAKE
dc.titleINJECTION OF RAMIPRIL INTO THE LATERAL VENTRICLE INTERFERES WITH THE DRINKING RESPONSE INDUCED BY PHARMACOLOGICAL AND NATURAL THIRST STIMULI
dc.typeOtro


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