Otro
Desenvolvimento de um método reflectométrico ambientalmente mais amigável para a determinação de metoclopramida em formulações farmacêuticas
Registro en:
Química Nova. Sociedade Brasileira de Química, v. 33, n. 2, p. 461-465, 2010.
0100-4042
10.1590/S0100-40422010000200039
S0100-40422010000200039
WOS:000275268400039
S0100-40422010000200039.pdf
0000-0003-0197-7369
Autor
Doretto, Keity Margareth
Gotardo, Mara Andréia
Pezza, Helena Redigolo
Pezza, Leonardo
Resumen
A simple and more environmentally friendly method by combined spot test-diffuse reflectance spectroscopy for determining metoclopramide in pharmaceutical formulations is described. The method is based on the reaction between metoclopramide and p-dimethylaminocinnamaldehyde, in the presence of HCl, producing a colored compound (λmáx = 580 nm) on the filter paper. The linear range was from 5.65 x 10-4-6.21x10-3 mol L-1 (r = 0.999). The limit of detection was 1.27 x 10-4 mol L-1. The proposed reflectometric method was applied successfully to the determination of metoclopramide in pharmaceuticals and it was favorably compared with the Brazilian or British Pharmacopoeia methods at 95% confidence level. Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)