An Unprecedented Neolignan Skeleton from Chimarrhis turbinata

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorCardoso, Carmen L.
dc.creatorCastro-Gamboa, Ian
dc.creatorBergamini, Giovana M.
dc.creatorCavalheiro, Alberto José
dc.creatorSilva, Dulce Helena Siqueira
dc.creatorLopes, Márcia Nasser
dc.creatorAraújo, Angela Regina
dc.creatorFurlan, Maysa
dc.creatorVerli, Hugo
dc.creatorBolzani, Vanderlan da Silva
dc.date2014-05-20T14:20:08Z
dc.date2016-10-25T17:41:27Z
dc.date2014-05-20T14:20:08Z
dc.date2016-10-25T17:41:27Z
dc.date2011-03-01
dc.date.accessioned2017-04-05T22:33:18Z
dc.date.available2017-04-05T22:33:18Z
dc.identifierJournal of Natural Products. Washington: Amer Chemical Soc, v. 74, n. 3, p. 487-491, 2011.
dc.identifier0163-3864
dc.identifierhttp://hdl.handle.net/11449/26048
dc.identifierhttp://acervodigital.unesp.br/handle/11449/26048
dc.identifier10.1021/np1007476
dc.identifierWOS:000288691800029
dc.identifier0000-0001-7616-9652
dc.identifierhttp://dx.doi.org/10.1021/np1007476
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/870868
dc.descriptionA lignan with a new skeleton named chimarrhinin (1) was isolated from an extract of the leaves of Chimarrhis turbinata, a Rubiaceae plant species. (13)C NMR spectrometric techniques including 1D and 2D experiments and HRESIMS provided unequivocal structural confirmation of this new C(6).C(3) skeleton type. The relative configuration of 1 was established by 2D (1)H-H analysis and J couplings, while its conformation was evaluated through molecular modeling using the RM1 semiempirical method, with the aid of coupling constants obtained by NMR analysis. The antioxidant activity of the new derivative 1 and two known and previously isolated phenolic derivatives (2 and 3) was investigated. An IC(50) value of 7.50 +/- 0.5 mu mol L(-1) was obtained for the new derivative 1, while 2 and 3 showed IC(50) values of 18.60 +/- 0.4 and 18.50 +/- 0.6 mu mol, respectively.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageeng
dc.publisherAmer Chemical Soc
dc.relationJournal of Natural Products
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.titleAn Unprecedented Neolignan Skeleton from Chimarrhis turbinata
dc.typeOtro


Este ítem pertenece a la siguiente institución