Peptídeos cíclicos de biomassa vegetal: características, diversidade, biossíntese e atividades biológicas
Química Nova. Sociedade Brasileira de Química, v. 32, n. 5, p. 1262-1277, 2009.
Picchi, Douglas Gatte
Altei, Wanessa Fernanda
Saito, Mônica Sue
Bolzani, Vanderlan da Silva
Cilli, Eduardo Maffud
Natural peptides are outstanding as the most promising macromolecules in the search for new drugs, especially those of cyclic nature. The higher plants revealed a very peculiar composition of their cyclic peptides, which distinguish themselves by a head-to-tail cyclization. It is possible to define two groups of cyclic peptides from plant biomass. Those called in this review as Eucyclopeptides formed by 2-12 amino acid, and Cyclotides considered as circular polypeptides, composed of 29-37 amino acid that retain three disulfides bridges in an arrangement known as cyclic cystine knot. Searching for plant peptides should form into a subject for scientific research in the forefront of great importance for bioprospecting natural products macromolecular.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)