Influence of TNF-alpha blockers on the oral prevalence of opportunistic microorganisms in ankylosing spondylitis patients

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorPereira, D. F. A.
dc.creatorPinheiro, M. M.
dc.creatorSilva, P. N. F.
dc.creatorTeodoro, G. R.
dc.creatorBrighenti, Fernanda Lourenção
dc.creatorKoga-Ito, C. Y.
dc.date2014-05-20T14:04:38Z
dc.date2016-10-25T17:10:19Z
dc.date2014-05-20T14:04:38Z
dc.date2016-10-25T17:10:19Z
dc.date2012-09-01
dc.date.accessioned2017-04-05T21:32:42Z
dc.date.available2017-04-05T21:32:42Z
dc.identifierClinical and Experimental Rheumatology. Pisa: Clinical & Exper Rheumatology, v. 30, n. 5, p. 679-685, 2012.
dc.identifier0392-856X
dc.identifierhttp://hdl.handle.net/11449/22678
dc.identifierhttp://acervodigital.unesp.br/handle/11449/22678
dc.identifierWOS:000310828600006
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/22935381
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/868057
dc.descriptionObjectivesTo compare the oral prevalence and antimicrobial susceptibility of candida spp. staphylococci, enterobacteriaceae, and pseudomonas spp. from ankylosing spondylitis (AS) patients receiving conventional and anti-TNF-alpha therapy.MethodsThe study included 70 AS patients, diagnosed according to the modified New York criteria (1984). The volunteers were divided into 2 groups: a biological group (AS BioG) (n=35) (on anti-TNF-a therapy) and a conventional group (AS ConvG) (n=35). The control group (ContG) (n=70) was made up of healthy individuals matched for age, gender, and oral conditions. After clinical examination, oral rinse samples were collected and plated in specific culture media. The number of colony-forming units per milliliter (cfu/ml) was obtained, and isolates were identified using the API system. Antimicrobial susceptibility tests were performed according to the NCCLS guidelines. Prevalence and counts of microorganisms were statistically compared between the 3 groups, using the Mann-Whitney and Chi-square tests. Significance level was set at 5%.ResultsIn both the AS BioG and the AS ConvG, staphylococci counts were higher than that in the ContG (p<0.0001).Candida albicans and staphylococcus epidermidis were the most commonly found species in all the groups. Serratia marcescens and klebsiella oxytoca were more prevalent in the AS BioG and the AS ConvG, respectively. Two candida isolates (2.8%) from the AS BioG and 5 (10.8%) from the AS ConvG were resistant to amphotericin B and 5-fluorocytosine. A low percentage of staphylococci isolates was resistant to amoxicillin, ciprofloxacin, and doxycycline.ConclusionHigher counts of staphylococci were observed in both AS groups, regardless of the current therapy, age, sex, and oral conditions. Anti-TNF-alpha therapy could not be correlated with increased counts of microorganisms.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageeng
dc.publisherClinical & Exper Rheumatology
dc.relationClinical and Experimental Rheumatology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectankylosing spondylitis
dc.subjectinfection
dc.subjectsuper-infection
dc.subjectoral microbiology
dc.subjectTNF-alpha blockers
dc.subjectcandida
dc.subjectstaphylococcus
dc.titleInfluence of TNF-alpha blockers on the oral prevalence of opportunistic microorganisms in ankylosing spondylitis patients
dc.typeOtro


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