In vitro antifungal susceptibility of Candida spp. oral isolates from HIV-positive patients and control individuals

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorBack Brito, Graziella Nuernberg
dc.creatorInocencio, Aline Cassia
dc.creatorRodrigues Querido, Silvia Maria
dc.creatorCardoso Jorge, Antonio Olavo
dc.creatorKoga-Ito, Cristiane Yumi
dc.date2014-05-20T14:04:34Z
dc.date2014-05-20T14:04:34Z
dc.date2011-01-01
dc.date.accessioned2017-04-05T21:32:29Z
dc.date.available2017-04-05T21:32:29Z
dc.identifierBrazilian Oral Research. São Paulo: Sociedade Brasileira de Pesquisa Odontologica, v. 25, n. 1, p. 28-33, 2011.
dc.identifier1806-8324
dc.identifierhttp://hdl.handle.net/11449/22655
dc.identifierS1806-83242011005000001
dc.identifierWOS:000311654700006
dc.identifierS1806-83242011005000001.pdf
dc.identifierhttp://dx.doi.org/10.1590/S1806-83242011005000001
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/868035
dc.descriptionOropharyngeal candidiasis is the most common fungal infection among HIV-positive patients. This condition can be treated with either systemic or topical antifungal agents; treatments are usually indicated empirically on the basis of clinical data. The knowledge of in vitro antifungal susceptibility is important to determine correct therapeutic guides for the treatment of fungal infections. Therefore, the objective of this study was to determine the antifungal susceptibility profile of oral Candida isolates from HIV-positive patients and control individuals. Amphotericin B, fluconazole, flucytosine, nystatin and ketoconazole were tested according to the methodology of microdilution proposed by the Clinical and Laboratory Standards Institute (CLSI); results were recorded in values of minimal inhibitory concentration (MIC). A total of 71 Candida isolates from HIV-positive patients were examined with the following species represented: C. albicans (59), C. tropicalis (9), C. glabrata (1), C. guilliermondii (1) and C. krusei (1). A total of 15 Candida isolates were evaluated from control individuals comprised of 11 C. albicans and 4 C. tropicalis samples. Our results demonstrated that the tested antifungal agents showed good activity for most isolates from both groups; however, variability in MIC values among isolates was observed.
dc.languageeng
dc.publisherSociedade Brasileira de Pesquisa Odontológica (SBPqO)
dc.relationBrazilian Oral Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHIV
dc.subjectAntifungal Agents
dc.subjectCandida
dc.titleIn vitro antifungal susceptibility of Candida spp. oral isolates from HIV-positive patients and control individuals
dc.typeOtro


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