In vitro and in vivo studies on CCR10 regulation by Annexin A1

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorRodrigues-Lisoni, F. C.
dc.creatorMehemet, D. K.
dc.creatorPeitl, P.
dc.creatorJohn, C. D.
dc.creatorTajara, E.
dc.creatorBuckingham, J. C.
dc.creatorSolito, E.
dc.date2014-05-20T14:01:32Z
dc.date2014-05-20T14:01:32Z
dc.date2006-02-01
dc.date.accessioned2017-04-05T21:25:34Z
dc.date.available2017-04-05T21:25:34Z
dc.identifierFebs Letters. Amsterdam: Elsevier B.V., v. 580, n. 5, p. 1431-1438, 2006.
dc.identifier0014-5793
dc.identifierhttp://hdl.handle.net/11449/21716
dc.identifier10.1016/j.febslet.2006.01.072
dc.identifierWOS:000235597700037
dc.identifierWOS000235597700037.pdf
dc.identifierhttp://dx.doi.org/10.1016/j.febslet.2006.01.072
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/867247
dc.descriptionThe mode of action of annexin A1 (ANXA1) is poorly understood. By using rapid subtraction hybridization we studied the effects of human recombinant ANXA1 and the N-terminal ANXA1 peptide on gene expression in a human larynx cell line. Three genes showed strong downregulation after treatment with ANXA1. In contrast, expression of CCR10, a seven transmembrane G-protein coupled receptor for chemokine CCL27 involved in mucosal immunity, was increased. Moreover the reduction in CCR10 expression induced by ANXA1 gene deletion was rescued by intravenous treatment with low doses of ANXA1. These findings provide new evidence that ANXA1 modulates gene expression. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationFEBS Letters
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectgene expression
dc.subjecthost defence
dc.subjectannexin A1-null mice
dc.subjectepithelial cells
dc.subjectannexin A1
dc.titleIn vitro and in vivo studies on CCR10 regulation by Annexin A1
dc.typeOtro


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