Nigriventrine: A low molecular mass neuroactive compound from the venom of the spider Phoneutria nigriventer

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorGomes, Paulo C.
dc.creatorde Souza, Bibiana M.
dc.creatorDias, Nathalia B.
dc.creatorCesar-Tognoli, Lilian M. M.
dc.creatorSilva-Filho, Luiz C.
dc.creatorTormena, Claudio F.
dc.creatorRittner, Roberto
dc.creatorRichardson, Michael
dc.creatorCordeiro, Marta N.
dc.creatorPalma, Mario Sergio
dc.date2014-05-20T13:54:59Z
dc.date2014-05-20T13:54:59Z
dc.date2011-02-01
dc.date.accessioned2017-04-05T21:11:54Z
dc.date.available2017-04-05T21:11:54Z
dc.identifierToxicon. Oxford: Pergamon-Elsevier B.V. Ltd, v. 57, n. 2, p. 266-274, 2011.
dc.identifier0041-0101
dc.identifierhttp://hdl.handle.net/11449/19670
dc.identifier10.1016/j.toxicon.2010.11.021
dc.identifierWOS:000287629400010
dc.identifierWOS000287629400010.pdf
dc.identifierhttp://dx.doi.org/10.1016/j.toxicon.2010.11.021
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/865478
dc.descriptionNigriventrine was isolated from the armed spider Phoneutria nigriventer, in which it constitutes about 0.4% of the total venom content. Its structure was determined to be [1,1`-(1-hydroxyhydrazine-1,2-diyl)bis(oxy)bis(4-hydroxy-2,6-dioxopiperidine-4 carboxylic acid)] by NMR, HR-ES/IMS and MS/MS methods. The intracerebroventricular application of nigriventrine in rat brain, followed by the detection of c-Fos protein expression, indicated that the compound was neuroactive in the motor cortex, sensory cortex, piriform cortex, median preoptic nucleus, dorsal endopiriform nucleus, lateral septal nucleus and hippocampus of rat brain. Nigriventrine causes convulsions in rats, even when peripherally applied. (c) 2010 Elsevier Ltd. All rights reserved.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageeng
dc.publisherPergamon-Elsevier B.V. Ltd
dc.relationToxicon
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSpider venom
dc.subjectSpectroscopy
dc.subjectLow molecular mass
dc.subjectNeurotoxin
dc.subjectGlutamate receptor
dc.subjectNatural product
dc.titleNigriventrine: A low molecular mass neuroactive compound from the venom of the spider Phoneutria nigriventer
dc.typeOtro


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