Otro
Nigriventrine: A low molecular mass neuroactive compound from the venom of the spider Phoneutria nigriventer
Registro en:
Toxicon. Oxford: Pergamon-Elsevier B.V. Ltd, v. 57, n. 2, p. 266-274, 2011.
0041-0101
10.1016/j.toxicon.2010.11.021
WOS:000287629400010
WOS000287629400010.pdf
Autor
Gomes, Paulo C.
de Souza, Bibiana M.
Dias, Nathalia B.
Cesar-Tognoli, Lilian M. M.
Silva-Filho, Luiz C.
Tormena, Claudio F.
Rittner, Roberto
Richardson, Michael
Cordeiro, Marta N.
Palma, Mario Sergio
Resumen
Nigriventrine was isolated from the armed spider Phoneutria nigriventer, in which it constitutes about 0.4% of the total venom content. Its structure was determined to be [1,1`-(1-hydroxyhydrazine-1,2-diyl)bis(oxy)bis(4-hydroxy-2,6-dioxopiperidine-4 carboxylic acid)] by NMR, HR-ES/IMS and MS/MS methods. The intracerebroventricular application of nigriventrine in rat brain, followed by the detection of c-Fos protein expression, indicated that the compound was neuroactive in the motor cortex, sensory cortex, piriform cortex, median preoptic nucleus, dorsal endopiriform nucleus, lateral septal nucleus and hippocampus of rat brain. Nigriventrine causes convulsions in rats, even when peripherally applied. (c) 2010 Elsevier Ltd. All rights reserved. Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)