Influence of different doses of retinoic acid on cardiac remodeling

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorFreire, Cristiana M. M.
dc.creatorGaiolla, Paula Schmidt Azevedo
dc.creatorMinicucci, Marcos Ferreira
dc.creatorOliveira Junior, Silvio A.
dc.creatorMartinez, Paula F.
dc.creatorNovo, Rosangela
dc.creatorChiuso-Minicucci, Fernanda
dc.creatorMatsubara, Beatriz Bojikian
dc.creatorMatsubara, Luiz Shiguero
dc.creatorOkoshi, Katashi
dc.creatorNovelli, Ethel L.
dc.creatorZornoff, Leonardo Antonio Mamede
dc.creatorPaiva, Sergio Alberto Rupp de
dc.date2014-05-20T13:50:55Z
dc.date2016-10-25T17:02:44Z
dc.date2014-05-20T13:50:55Z
dc.date2016-10-25T17:02:44Z
dc.date2011-07-01
dc.date.accessioned2017-04-05T21:04:11Z
dc.date.available2017-04-05T21:04:11Z
dc.identifierNutrition. New York: Elsevier B.V., v. 27, n. 7-8, p. 824-828, 2011.
dc.identifier0899-9007
dc.identifierhttp://hdl.handle.net/11449/18173
dc.identifierhttp://acervodigital.unesp.br/handle/11449/18173
dc.identifier10.1016/j.nut.2010.08.011
dc.identifierWOS:000292410200014
dc.identifierhttp://dx.doi.org/10.1016/j.nut.2010.08.011
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/864438
dc.descriptionObjective: The role of retinoic acid in promoting postnatal heart alterations is still unclear. The aim of this study was to evaluate whether the cardiac alterations caused by all-trans- retinoic acid (ATRA) in normal adult rat hearts are physiologic or pathologic and if these alterations are dose-dependent.Methods: Rats were allocated into a control group that received a diet without ATRA (n = 16), a group that received 0.3 mg of ATRA/kg of diet (n = 17), a group that received a diet containing 10 mg of ATRA/kg (n = 18), or a group that received 50 mg of ATRA/kg in the diet (n = 18). After 4 wk, the animals were evaluated echocardiographically, morphologically, and biochemically.Results: The 50-mg ATRA group presented cardiac hypertrophy with maintenance of cardiac geometry and increased systolic function, whereas diastolic function was similar to that of the control group. In addition, progressive increases in the ATRA dose resulted in gradual augmentations of left atrial diameter, left ventricular diastolic and systolic diameters, left ventricular mass index, cardiac output, cardiac index, and aortic velocity. The ATRA did not produce alterations in interferon-gamma and tumor necrosis factor-alpha cardiac levels, interstitial collagen volume fraction, or the intensity and localization of connexin-43. In addition, no alteration was observed in beta-hydroxyacyl coenzyme A dehydrogenase, lactate dehydrogenase, or citrate synthase, suggesting that cardiac energetic metabolism was preserved with ATRA.Conclusion: These results suggest that ATRA produced dose-dependent effects and cardiac remodeling that is more compatible with a physiologic response. (C) 2011 Elsevier B.V. All rights reserved.
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageeng
dc.publisherElsevier B.V.
dc.relationNutrition
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectRetinoic acid
dc.subjectCardiac remodeling
dc.subjectEnergetic metabolism
dc.subjectConnexin-43
dc.subjectCytokines
dc.titleInfluence of different doses of retinoic acid on cardiac remodeling
dc.typeOtro


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