Otro
Molecular approaches for eco-epidemiological studies of Paracoccidioides brasiliensis
Registro en:
Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 104, n. 4, p. 636-643, 2009.
0074-0276
10.1590/S0074-02762009000400018
S0074-02762009000400018
WOS:000269466900018
S0074-02762009000400018.pdf
Autor
Richini-Pereira, Virgínia Bodelão
Bosco, Sandra de Moraes Gimenes
Theodoro, Raquel Cordeiro
Macoris, Severino Assis da Graça
Bagagli, Eduardo
Resumen
Medical mycology has greatly benefited from the introduction of molecular techniques. New knowledge on molecular genetics has provided both theoretical and practical frameworks, permitting important advances in our understanding of several aspects of pathogenic fungi. Considering Paracoccidioides brasiliensis in particular, important eco-epidemiological aspects, such as environmental distribution and new hosts were clarified through molecular approaches. These methodologies also contributed to a better understanding about the genetic variability of this pathogen; thus, P. brasiliensis is now assumed to represent a species complex. The present review focuses on some recent findings about the current taxonomic status of P. brasiliensis, its phylogenetic and speciation processes, as well as on some practical applications for the molecular detection of this pathogen in environmental and clinical materials. Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)