Otro
Virulence attenuation and phenotypic variation of Paracoccidioides brasiliensis isolates obtained from armadillos and patients
Registro en:
Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 101, n. 3, p. 331-334, 2006.
0074-0276
10.1590/S0074-02762006000300019
S0074-02762006000300019
S0074-02762006000300019.pdf
Autor
Macoris, SAG
Sugizaki, MF
Peraçoli, MTS
Bosco, SMG
Hebeler-Barbosa, F.
Simões, LB
Theodoro, RC
Trinca, LA
Bagagli, Eduardo
Resumen
Paracoccidioides brasiliensis is the etiological agent of paracoccidioidomycosis, the most important systemic mycosis in Latin America. The virulence profiles of five isolates of P. brasiliensis were studied in two different moments and correlated with some colonial phenotypic aspects. We observed a significant decrease in the virulence and an intense phenotypic variation in the mycelial colony. The recognition of all ranges of phenotypic and virulence variation of P. brasiliensis, as well as its physiological and genetic basis, will be important for a better comprehension of its pathogenic and epidemiological features.