Otro
Evaluation of the analgesic and antiedematogenic activities of Quassia amara bark extract
Registro en:
Journal of Ethnopharmacology. Clare: Elsevier Sci Ireland Ltd, v. 85, n. 1, p. 19-23, 2003.
0378-8741
10.1016/S0378-8741(02)00334-3
WOS:000181227100004
0000-0002-8645-3777
Autor
Toma, W.
Gracioso, J. S.
Hiruma-Lima, C. A.
Andrade, FDP
Vilegas, Wagner
Brito, ARMS
Resumen
We evaluated the possible antiedematogenic, antinociceptive and/or sedative effects of four different extracts obtained from the bark of Quassia amara namely, 70% ethanol (70EtOH), 100% ethanol (100EtOH), dichloromethane (DCM) and hexane extracts (HEX). The oral administration (100, 250 and 500 mg/kg) of these extracts did not show significant effects in any experiment. However, when administered intraperitoneally, the HEX extract decreased the paw edema induced by carrageenan, showed antinociceptive effects on the hot-plate test and on acetic acid-induced writhing, and showed sedative effects on pentobarbital-induced sleep. Naloxone did not reverse the antinociceptive effect of this extract. In conclusion, although the mechanisms are uncertain, the results demonstrated that these effects are apparently related to sedative and muscle relaxant or psychomimetic activities of the HEX extract of the plant. (C) 2002 Elsevier B.V. Ireland Ltd. All rights reserved.