Effects of Coccoloba uvifera L. on UV-stimulated melanocytes

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorPedroso Sanches Silveira, Jessica Eleonora
dc.creatorVelazquez Pereda, Maria del Carmen
dc.creatorEberlin, Samara
dc.creatorDieamant, Gustavo Campos
dc.creatorDi Stasi, Luiz Claudio
dc.date2014-05-20T13:49:16Z
dc.date2016-10-25T17:01:47Z
dc.date2014-05-20T13:49:16Z
dc.date2016-10-25T17:01:47Z
dc.date2008-12-01
dc.date.accessioned2017-04-05T21:00:49Z
dc.date.available2017-04-05T21:00:49Z
dc.identifierPhotodermatology Photoimmunology & Photomedicine. Malden: Wiley-blackwell, v. 24, n. 6, p. 308-313, 2008.
dc.identifier0905-4383
dc.identifierhttp://hdl.handle.net/11449/17543
dc.identifierhttp://acervodigital.unesp.br/handle/11449/17543
dc.identifier10.1111/j.1600-0781.2008.00382.x
dc.identifierWOS:000260824300008
dc.identifierhttp://dx.doi.org/10.1111/j.1600-0781.2008.00382.x
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/864001
dc.descriptionExposure to ultraviolet (UV) radiation induces generation of reactive oxygen species, production of proinflammatory cytokines and melanocyte-stimulating hormone (MSH) as well as increase in tyrosinase activity. The potential photoprotective effects of Coccoloba uvifera extract (CUE) were evaluated in UV-stimulated melanocytes.Human epidermal melanocytes were used as an in vitro model to evaluate the effects of CUE on the production interleukin-1 alpha (IL-1 alpha), tumor necrosis factor alpha (TNF-alpha), and alpha-MSH under basal and UV-stimulated conditions. Antioxidant and anti-tyrosinase activities were also evaluated in membrane lipid peroxidation and mushroom tyrosinase assay, respectively.Coccoloba uvifera L. showed antioxidant and anti-tyrosinase activities and also inhibited the production of IL-1 alpha, TNF-alpha and alpha-MSH in melanocytes subjected to UV radiation (P < 0.01). Moreover, CUE inhibited the activity of tyrosine kinase in cell culture under basal and UV radiation conditions (P < 0.001), corroborating the findings of the mushroom tyrosinase assay.This study supports the photoprotective potential of CUE.
dc.languageeng
dc.publisherWiley-Blackwell
dc.relationPhotodermatology Photoimmunology & Photomedicine
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectalpha-MSH
dc.subjectIL-1 alpha
dc.subjectmelanocyte
dc.subjectTNF-alpha
dc.subjecttyrosinase
dc.titleEffects of Coccoloba uvifera L. on UV-stimulated melanocytes
dc.typeOtro


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