Stimulation of IL-6 Cytokines in Fibroblasts by Toll-like Receptors 2

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorSouza, Pedro Paulo Chaves de
dc.creatorPalmqvist, P.
dc.creatorLundgren, I.
dc.creatorLie, A.
dc.creatorCosta-Neto, C. M.
dc.creatorLundberg, P.
dc.creatorLerner, U. H.
dc.date2014-05-20T13:46:08Z
dc.date2016-10-25T16:59:57Z
dc.date2014-05-20T13:46:08Z
dc.date2016-10-25T16:59:57Z
dc.date2010-08-01
dc.date.accessioned2017-04-05T20:54:17Z
dc.date.available2017-04-05T20:54:17Z
dc.identifierJournal of Dental Research. Thousand Oaks: Sage Publications Inc, v. 89, n. 8, p. 802-807, 2010.
dc.identifier0022-0345
dc.identifierhttp://hdl.handle.net/11449/16296
dc.identifierhttp://acervodigital.unesp.br/handle/11449/16296
dc.identifier10.1177/0022034510366898
dc.identifierWOS:000280194800008
dc.identifierhttp://dx.doi.org/10.1177/0022034510366898
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/863124
dc.descriptionThe osteotropic interleukin-6 (IL-6) types of cytokines IL-6, IL-11, and leukemia inhibitory factor (LIF), but not oncostatin M, are expressed by human gingival fibroblasts, and their expressions are regulated by IL-1 and tumor necrosis factor-a (TNF-alpha). In the present study, we investigated whether signaling through Toll-like receptor 2 (TLR2) can affect the expression of these cytokines in human gingival fibroblasts. Lipopolysaccharide (LPS) from P. gingivalis was found to stimulate IL-6 and LIF mRNA and protein, but not IL-11 or OSM mRNA. Using two synthetic ligands acting specifically at TLR2 and siRNA knockdown of TLR2, we demonstrated the important role of TLR2 in the stimulation of IL-6 and LIF in gingival fibroblasts. Analysis of these data suggests that signaling through the innate immune system controls the expression of osteotropic cytokines in human gingival fibroblasts.
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageeng
dc.publisherSage Publications Inc
dc.relationJournal of Dental Research
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectgingival fibroblasts
dc.subjectIL-6
dc.subjectLIF
dc.subjectIL-11
dc.subjectTLR
dc.titleStimulation of IL-6 Cytokines in Fibroblasts by Toll-like Receptors 2
dc.typeOtro


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