Lesions in the central amygdala impair sodium intake induced by the blockade of the lateral parabrachial nucleus

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorAndrade-Franze, Glaucia M. F.
dc.creatorAndrade, Carina A. F.
dc.creatorDe Luca, Laurival A.
dc.creatorDe Paula, Patricia M.
dc.creatorColombari, Debora S. A.
dc.creatorMenani, José Vanderlei
dc.date2014-05-20T13:46:03Z
dc.date2016-10-25T16:59:54Z
dc.date2014-05-20T13:46:03Z
dc.date2016-10-25T16:59:54Z
dc.date2010-05-21
dc.date.accessioned2017-04-05T20:54:04Z
dc.date.available2017-04-05T20:54:04Z
dc.identifierBrain Research. Amsterdam: Elsevier B.V., v. 1332, p. 57-64, 2010.
dc.identifier0006-8993
dc.identifierhttp://hdl.handle.net/11449/16261
dc.identifierhttp://acervodigital.unesp.br/handle/11449/16261
dc.identifier10.1016/j.brainres.2010.03.055
dc.identifierWOS:000278251500006
dc.identifierhttp://dx.doi.org/10.1016/j.brainres.2010.03.055
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/863096
dc.descriptionThe blockade of the lateral parabrachial nucleus (LPBN) with the GABAergic receptor agonist muscimol induces strong hypertonic NaCl intake in satiated and normovolemic rats, whereas lesions of the central nucleus of the amygdala (CeA) reduce sodium intake induced by different protocols. In the present study we investigated the effects of bilateral lesions of the CeA on water and 0.3 M NaCl intake induced by GABAergic receptor activation with bilateral injections of muscimol into the LPBN in satiated rats. Male Holtzman rats (n=6-10) with bilateral sham or electrolytic lesions (2 mA; 10 s) of the CeA and stainless steel cannulas implanted bilaterally in the LPBN were used. Bilateral injections of muscimol (0.5 nmol/0.2 mu l) into the LPBN in satiated sham-lesioned rats induced 0.3 M NaCl intake (16.1 +/- 5.4 ml/4 h, vs. saline: 1.3 +/- 0.5 ml/4 h) and water intake (8.1 +/- 3.5 ml/4 h, vs. saline: 1.6 +/- 0.5 ml/4 h). Bilateral lesions of the CeA (3 days) abolished 0.3 M NaCl intake (0.1 +/- 0.1 ml/4 h) and water intake (0.1 +/- 0.1 ml/4 h) induced by bilateral injections of muscimol into the LPBN in satiated rats. The present results show that water and 0.3 M NaCl intake induced by the blockade of LPBN neurons with muscimol depends on the integrity of the CeA, suggesting that facilitatory mechanisms present in the CeA are essential for water and hypertonic NaCl intake that arises after the blockade of the inhibitory mechanisms of the LPBN with muscimol. (C) 2010 Elsevier B.V. All rights reserved.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageeng
dc.publisherElsevier B.V.
dc.relationBrain Research
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSodium appetite
dc.subjectParabrachial nucleus
dc.subjectAmygdala
dc.subjectThirst
dc.subjectMuscimol
dc.subjectGABA
dc.titleLesions in the central amygdala impair sodium intake induced by the blockade of the lateral parabrachial nucleus
dc.typeOtro


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