Otro
Involvement of forebrain imidazoline and alpha(2)-adrenergic receptors in the antidipsogenic response to moxonidine
Registro en:
Agmatine and Imidazolines: Their Novel Receptors and Enzymes. New York: New York Acad Sciences, v. 1009, p. 262-264, 2003.
0077-8923
10.1196/annals.1304.032
WOS:000189443800032
Autor
Andrade, CAF
Oliveira, L. B.
Martinez, G.
Silva, DCF
De Luca, L. A.
Menani, José Vanderlei
Resumen
We investigated the participation of central alpha(2)-adrenoceptors and imidazoline receptors in the inhibition of water deprivation-induced water intake in rats. The alpha(2)-adrenoceptor and imidazoline antagonist idazoxan (320 nmol), but not the alpha(2)-adrenoceptor antagonist yohimbine, abolished the antidipsogenic effect of moxonidine (alpha(2)-adrenoceptor and imidazoline agonist, 20 nmol) microinjected into the medial septal area. Yohimbine abolished the antidipsogenic effect of moxonidine intracerebroventricularly. Therefore, central moxonidine may inhibit water intake acting independently on both imidazoline receptors and alpha(2)-adrenoceptors at different forebrain sites.