Otro
Evaluation of chitosan gel as antibiotic and photosensitizer delivery
Registro en:
Drug Delivery. London: Informa Healthcare, v. 15, n. 7, p. 417-422, 2008.
1071-7544
10.1080/10717540802007433
WOS:000258620600002
Autor
Fontana, Carla Raquel
dos Santos Junior, David Sotero
Bosco, Joseane Maria
Spolidorio, Denise M.
Marcantonio, Rosemary Adriana Chierici
Resumen
This work suggests the use of chitosan gel imbued with the photosensitizer Photogem and with the antibiotic Tetraclin as a possible drug delivery system. The results reveal a decrease in the photosensitizer level of toxicity. Besides, the interaction between Photogem and chitosan gel causes a red shift in the photosensitizer spectrum, increasing its absorption in the therapeutic window (600-700 nm). These characteristics indicate this compound as a promising natural polymer-based photosensitizer carrier for photodynamic therapy. In summary, our results show that pure and doped chitosan gel may have potential application for antimicrobial action, being an excellent alternative when local control of the drug administration, provided by the gel, is required. Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)