Dissertação
Efeito do laser sobre a cicatrização cutânea e nos parâmetros do estresse oxidativo: uma revisão sistemática
Fecha
2023-04-30Autor
Irber, Paola Flores
Institución
Resumen
The laser is a high-tech device, considered an amplified light produced by electromagnetic
radiation that manifests itself as monochromatic light. Low-intensity laser therapy (LIBT) aims
to favor tissue regeneration, by increasing the mitotic speed of cells, the laser stimulates
epithelial cells, favoring efficient healing in rapid conditions. Cutaneous healing is complex,
with vascular/cellular alterations, its process also activates oxidant and inflammatory
components, such as cytokines and reactive oxygen species (ROS), which, if produced in
excess, damage the tissue, causing oxidative stress, which can lead to to cell death
(apoptosis). There is evidence that laser therapy influences parameters of oxidative stress
such as changes in the activity of antioxidant enzymes and a decrease in reactive oxygen
species, but its effects on the cellular mechanism and its influence on oxidative parameters in
the treatment of injuries are still not well understood. Thus, the objective of this dissertation
was, through this systematic review, to carry out a survey of studies that relate the effects of
laser therapy on skin healing from the modulation of oxidative stress in animal models. This
study consisted of a systematic review of the literature. Original studies that evaluated the
effect of laser on skin healing and oxidative stress in animals were included. The search for
articles was carried out in the databases: PubMed, Embase and Web of Science. The
methodological quality of the studies was assessed using the adapted PEDro scale. A
qualitative and descriptive analysis of the selected studies was carried out. Six studies were
included, all articles showed significant results in the modulation of oxidative stress, reducing
oxidant markers (superoxide anion) and activator of apoptosis (cytochrome c), and mainly
increasing the antioxidant enzymatic defense (Catalase, Superoxide Dismutase and
Glutathione Peroxidase). The present dissertation provided further research on the action of
TBLI on skin healing and oxidative stress parameters. TBLI is effective in healing the skin, as
well as modulating the increase in cicatricial oxidative stress by acting on the cellular
antioxidant/oxidant balance. However, there is a clear need for further studies to elucidate the
mechanisms of these effects, especially in mitochondrial analyses.